Biochemistry, Polyol Or Sorbitol Pathways
| Autor: | Srikanth KK; Creighton University, Orrick JA; Boston University |
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| Jazyk: | angličtina |
| Zdroj: | 2022 Jan. |
| Abstrakt: | The sorbitol or polyol pathway is a two-step metabolic pathway that converts glucose into fructose. This pathway is thought to play a prominent role in explaining the pathogenesis of complications in patients with end-stage diabetes. In light of this, this activity presents the biochemistry behind this pathway, summarizes the individual reactions and their importance, reviews the prevailing hypothesis explaining why this pathway plays a role in end-stage diabetes, and explores the clinical significance of the polyol pathway with potential for treatment in diabetic patients. [1] (Copyright © 2022, StatPearls Publishing LLC.) |
| Databáze: | MEDLINE |
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