Biochemistry, Protein Targeting and I Cell Diseases
| Autor: | Lavadi RS; Vydehi Institute of Medical Sciences & Research Centre, Orrick JA; Boston University |
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| Jazyk: | angličtina |
| Zdroj: | 2022 Jan. |
| Abstrakt: | Proteins in the body are produced by the cytoplasmic ribosomes and the rough endoplasmic reticulum (RER). The cytoplasmic ribosomes produce proteins necessary for cytoplasmic, mitochondrial, and peroxisomal functions. The RER produces the proteins required for endoplasmic, Golgi, and lysosomal functions. These proteins must be localized appropriately to carry out their intracellular and extracellular tasks. The process of directing proteins to their appropriate location is termed protein targeting. Protein targeting may use vesicles depending on the source of the protein. Proteins from cytoplasmic ribosomes are not directed via vesicles, whereas proteins from the RER are localized in the cellular apparatus via vesicles. In protein targeting, many proteins are favorably modified by enzymes and helper proteins to improve the delivery. In the event of genetic mutations, proteins may localize inappropriately, leading to abnormal cellular function. This process's alteration can result in fatal metabolic diseases such as inclusion-cell disease (ICD). (Copyright © 2022, StatPearls Publishing LLC.) |
| Databáze: | MEDLINE |
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