Rapid Plastic Deformation of Cancer Cells Correlates with High Metastatic Potential.

Autor: Yan Z; Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China.; HKU-Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen, Guangdong, China., Xia X; Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China.; HKU-Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen, Guangdong, China., Cho WC; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China., Au DW; Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China., Shao X; Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China., Fang C; Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China.; HKU-Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen, Guangdong, China., Tian Y; Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China.; HKU-Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen, Guangdong, China., Lin Y; Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China.; HKU-Shenzhen Institute of Research and Innovation (HKU-SIRI), Shenzhen, Guangdong, China.; Advanced Biomedical Instrumentation Centre, Hong Kong Science Park, Shatin, New Territories, Hong Kong.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2022 Apr; Vol. 11 (8), pp. e2101657. Date of Electronic Publication: 2022 Jan 17.
DOI: 10.1002/adhm.202101657
Abstrakt: Metastasis plays a crucial role in tumor development, however, lack of quantitative methods to characterize the capability of cells to undergo plastic deformations has hindered the understanding of this important process. Here, a microfluidic system capable of imposing precisely controlled cyclic deformation on cells and therefore probing their viscoelastic and plastic characteristics is developed. Interestingly, it is found that significant plastic strain can accumulate rapidly in highly invasive cancer cell lines and circulating tumor cells (CTCs) from late-stage lung cancer patients with a characteristic time of a few seconds. In constrast, very little irreversible deformation is observed in the less invasive cell lines and CTCs from early-stage lung cancer patients, highlighting the potential of using the plastic response of cells as a novel marker in future cancer study. Furthermore, author showed that the observed irreversible deformation should originate mainly from cytoskeleton damage, rather than plasticity of the cell nucleus.
(© 2022 Wiley-VCH GmbH.)
Databáze: MEDLINE
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