Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder.

Autor: Keim SA; Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA. sarah.keim@nationwidechildrens.org.; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA. sarah.keim@nationwidechildrens.org.; Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH, USA. sarah.keim@nationwidechildrens.org., Jude A; Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA., Smith K; Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA., Khan AQ; Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA., Coury DL; Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA., Rausch J; Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA., Udaipuria S; Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA., Norris M; Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA.; Department of Psychology, College of Arts and Sciences, The Ohio State University, Columbus, OH, USA., Bartram LR; Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA., Narayanan AR; Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA., Rogers LK; Nationwide Children's Hospital, 700 Children's Dr, Columbus, OH, 43205, USA.; Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA.
Jazyk: angličtina
Zdroj: Journal of autism and developmental disorders [J Autism Dev Disord] 2022 Dec; Vol. 52 (12), pp. 5342-5355. Date of Electronic Publication: 2022 Jan 11.
DOI: 10.1007/s10803-021-05396-9
Abstrakt: This double-blind, randomized controlled trial, tested fatty acid (FA) supplementation in children (ages 2- < 6 years) recently diagnosed with Autism Spectrum Disorder (ASD). Participants received daily oral FA supplement containing omega-3 and omega-6 FA, or a placebo for 90 days based on participant weight. Erythrocyte FAs and the cytokines, IL-1β, IL-2, IFNγ, were measured in plasma obtained from serial blood collections. Treatment increased omega-3 and omega-6 FA levels (1.40 mol% for EPA and 1.62 mol% for DHA) and reduced IL-2 levels compared to placebo (- 0.17 pg/mL, 95% CI - 0.31, - 0.02, d = - 0.62). Omega 3-6 treatment was tolerable and adherence was greater than 70%. Future research will assess the effects of Omega 3-6 treatment on ASD symptoms. Registered on 06/08/2018 with ClinicalTrials.gov: NCT03550209.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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