Fatal Toxoplasma gondii myocarditis in an urban pet dog.

Autor: Dorsch MA; Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental La Estanzuela, Ruta 50 km 11, La Estanzuela 70000, Colonia, Uruguay., Cesar D; Private Practice, Montevideo, Uruguay., Bullock HA; Synergy America Inc., Atlanta, GA, USA., Uzal FA; California Animal Health and Food Safety (CAHFS) Laboratory, University of California Davis, San Bernardino, CA, USA., Ritter JM; Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention (CDC), Atlanta, GA, USA., Giannitti F; Plataforma de Investigación en Salud Animal, Instituto Nacional de Investigación Agropecuaria (INIA), Estación Experimental La Estanzuela, Ruta 50 km 11, La Estanzuela 70000, Colonia, Uruguay. Electronic address: fgiannitti@inia.org.uy.
Jazyk: angličtina
Zdroj: Veterinary parasitology, regional studies and reports [Vet Parasitol Reg Stud Reports] 2022 Jan; Vol. 27, pp. 100659. Date of Electronic Publication: 2021 Nov 03.
DOI: 10.1016/j.vprsr.2021.100659
Abstrakt: A 70-day-old Boxer dog from a household in Montevideo, Uruguay, died after presenting neurologic, respiratory, and gastrointestinal signs for 6 days. Autopsy findings included lymphadenomegaly, ascites and hepatomegaly. Histopathology revealed severe widespread lymphohistiocytic and plasmacytic myocarditis with cardiomyocyte necrosis, mineralization and numerous intrasarcoplasmic protozoa immunoreactive with anti-Toxoplasma gondii antisera on immunohistochemistry. The protozoa were ultrastructurally confirmed as T. gondii by transmission electron microscopy. Other lesions included diffuse centrilobular hepatocellular necrosis, multifocal lymphohistiocytic portal hepatitis and interstitial nephritis. Other causes of myocarditis, including Neospora caninum, Trypanosoma cruzi, Sarcocystis neurona, canine distemper virus, and canine parvovirus were ruled out by immunohistochemistry. Toxoplasma gondii infections in dogs are usually subclinical; however, clinical disease with fatal outcome can occur. To our knowledge, this is the first report of fatal toxoplasmosis in a dog in Uruguay. This case raises awareness for dogs as sentinels and possible sources of human toxoplasmosis in urban settings in Uruguay.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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