Complexes of Glucarolactones with Water-Soluble Copolymers of N-Vinylpyrrolidone with N-Vinylamine as Inhibitors of β-Glucuronidase Efficacy.

Autor: Krasikov VD; Federal State Budgetary Institution of Science Institute of Macromolecular Compounds, Russian Academy of Sciences (IMC RAS), 199004 Saint Petersburg, Russia., Santuryan YG; Federal State Budgetary Institution of Science Institute of Macromolecular Compounds, Russian Academy of Sciences (IMC RAS), 199004 Saint Petersburg, Russia., Malahova II; Federal State Budgetary Institution of Science Institute of Macromolecular Compounds, Russian Academy of Sciences (IMC RAS), 199004 Saint Petersburg, Russia., Ivanov AG; Federal State Budgetary Institution of Science Institute of Macromolecular Compounds, Russian Academy of Sciences (IMC RAS), 199004 Saint Petersburg, Russia., Gorshkov NI; Federal State Budgetary Institution of Science Institute of Macromolecular Compounds, Russian Academy of Sciences (IMC RAS), 199004 Saint Petersburg, Russia., Panarin EF; Federal State Budgetary Institution of Science Institute of Macromolecular Compounds, Russian Academy of Sciences (IMC RAS), 199004 Saint Petersburg, Russia.
Jazyk: angličtina
Zdroj: Polymers [Polymers (Basel)] 2021 Dec 28; Vol. 14 (1). Date of Electronic Publication: 2021 Dec 28.
DOI: 10.3390/polym14010105
Abstrakt: Water-soluble complexes of N-vinylpyrrolidone/N-vinylamine copolymers with lactones of D-glucuronic acid were obtained and characterized by chromatographic, spectral, and hydrodynamic methods. The complexes efficiently inhibited the enzyme β-glucuronidase that causes the appearance of bladder tumors. The products demonstrated prolonged action and were stable during storage.
Databáze: MEDLINE
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