Hearing Loss in Beta-Thalassemia: Systematic Review.

Autor: Tartaglione I; Department of General and Specialized Surgery for Women and Children, Università degli Studi della Campania 'Luigi Vanvitelli', 80131 Napoli, Italy., Carfora R; Department of General and Specialized Surgery for Women and Children, Università degli Studi della Campania 'Luigi Vanvitelli', 80131 Napoli, Italy., Brotto D; Otorhinolaryngology-Head and Neck Section, Department of Neurosciences, University of Padova, 35122 Padova, Italy., Barillari MR; Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy., Costa G; Division of Phoniatrics and Audiology, Department of Mental and Physical Health and Preventive Medicine, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy., Perrotta S; Department of General and Specialized Surgery for Women and Children, Università degli Studi della Campania 'Luigi Vanvitelli', 80131 Napoli, Italy., Manara R; Neuroradiology, Department of Neuroscience, University of Padova, 35128 Padova, Italy.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2021 Dec 25; Vol. 11 (1). Date of Electronic Publication: 2021 Dec 25.
DOI: 10.3390/jcm11010102
Abstrakt: In the last half century, the life expectancy of beta-thalassemia patients has strikingly increased mostly due to regular blood transfusions and chelation treatments. The improved survival, however, has allowed for the emergence of comorbidities, such as hearing loss, with a non-negligible impact on the patients' quality of life. This thorough review analyzes the acquired knowledge regarding hearing impairment in this hereditary hemoglobinopathy, aiming at defining its prevalence, features, course, and possible disease- or treatment-related pathogenic factors. Following PRISMA criteria, we retrieved 60 studies published between 1979 and 2021. Diagnostic tools and criteria, forms of hearing impairment, correlations with beta-thalassemia phenotypes, age and sex, chelation treatment and laboratory findings including iron overload, were carefully searched, analyzed and summarized. In spite of the relatively high number of studies in the last 40 years, our knowledge is rather limited, and large prospective studies with homogeneous diagnostic tools and criteria are required to define all the aforementioned issues. According to the literature, the overall prevalence rate of hearing impairment is 32.3%; age, sex, and laboratory findings do not seem to correlate with hearing deficits, while the weak relationship with clinical phenotype and chelation treatment seems to highlight the presence of further yet to be identified pathogenic factors.
Databáze: MEDLINE
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