| Autor: |
Iannuzzi A; Department of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy., Giallauria F; Department of Translational Medical Sciences, Federico II University of Naples, 80131 Naples, Italy., Gentile M; Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy., Rubba P; Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy., Covetti G; Department of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy., Bresciani A; Department of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy., Aliberti E; Department of Gastroenterology, North Tees University Hospital, Stockton-on-Tees TS19 8PE, UK., Cuomo G; Department of Translational Medical Sciences, Federico II University of Naples, 80131 Naples, Italy., Panico C; Diagnostic and Interventional Radiology-Policlinico Gemelli Foundation, 00168 Rome, Italy., Tripaldella M; Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy., Giusti MA; Diabetes and Islet Transplantation Unit, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT (Istituto Mediterraneo per I Trapianti e Terapie ad alta specializzazione), UPMC Italy, 90127 Palermo, Italy., Mattina A; Diabetes and Islet Transplantation Unit, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT (Istituto Mediterraneo per I Trapianti e Terapie ad alta specializzazione), UPMC Italy, 90127 Palermo, Italy., Iannuzzo G; Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy. |
| Abstrakt: |
Atherogenic lipoproteins (particularly, very low-density lipoproteins, VLDL) are associated with subclinical atherosclerosis. The present study aims at evaluating whether routinely analysed lipid parameters are associated with carotid intima-media thickness, a proxy for subclinical atherosclerosis. Lipid parameters from 220 post-menopausal women undergoing ultrasound investigation of the carotid arteries were analysed. Forty-five percent of women showed subclinical atherosclerosis on carotid ultrasound. The mean carotid intima-media thickness was 1.26 ± 0.38 mm. The mean value of the non-HDL-C/HDL-C ratio was 3.1 ± 1.2. Univariate analysis showed a significant association between non-HDL-C/HDL-C ratio and intima-media thickness (r = 0.21, p = 0.001). After adjusting for cardiovascular risk factors (age, systolic blood pressure, smoking, body mass index Homeostasis model assessment: insulin resistance and high-sensitivity C-Reactive-Protein), multivariate analysis showed a significant association between non-HDL-C/HDL-C ratio and intima-media thickness (β = 0.039, p = 0.04). Logistic regression analysis showed that the highest tertile of the non-HDL-C/HDL-C ratio was associated with the presence of carotid plaques (OR = 3.47, p = 0.003). Finally, a strong correlation between non-HDL-C/HDL-C ratio and cholesterol bound to VLDL (r = 0.77, p < 0.001) has been found. Non-HDL-C/HDL-C ratio is associated with the presence of carotid atherosclerosis in post-menopausal women and is strongly correlated to VLDL-C levels. |
