| Autor: |
Gutiérrez D; Laboratory of Natural Product Chemistry, Center of Aquatic Biotechnology, Department of Environmental Sciences, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago 3363, Chile., Benavides A; Laboratory of Natural Product Chemistry, Center of Aquatic Biotechnology, Department of Environmental Sciences, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago 3363, Chile., Valenzuela B; Laboratory of Natural Product Chemistry, Center of Aquatic Biotechnology, Department of Environmental Sciences, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago 3363, Chile., Mascayano C; Laboratory of Computational Simulations and Rational Drug Design, Department of Environmental Sciences, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago 3363, Chile., Aldabaldetrecu M; Laboratory of Coordination Compounds and Supramolecularity, Faculty of Chemistry and Biology, University of Santiago of Chile, Santiago 9170002, Chile., Olguín A; Laboratory of Natural Product Chemistry, Center of Aquatic Biotechnology, Department of Environmental Sciences, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago 3363, Chile., Guerrero J; Laboratory of Coordination Compounds and Supramolecularity, Faculty of Chemistry and Biology, University of Santiago of Chile, Santiago 9170002, Chile., Modak B; Laboratory of Natural Product Chemistry, Center of Aquatic Biotechnology, Department of Environmental Sciences, Faculty of Chemistry and Biology, University of Santiago de Chile, Santiago 3363, Chile. |
| Abstrakt: |
The aquatic infectious pancreatic necrosis virus (IPNV) causes a severe disease in farmed salmonid fish that generates great economic losses in the aquaculture industry. In the search for new tools to control the disease, in this paper we show the results obtained from the evaluation of the antiviral effect of [Cu(NN 1 ) 2 ](ClO 4 ) Cu(I) complex, synthesized in our laboratory, where the NN 1 ligand is a synthetic derivate of the natural compound coumarin. This complex demonstrated antiviral activity against IPNV at 5.0 and 15.0 µg/mL causing a decrease viral load 99.0% and 99.5%, respectively. The Molecular Docking studies carried out showed that the copper complex would interact with the VP2 protein, specifically in the S domain, altering the process of entry of the virus into the host cell. |
