Effects of Various Muscle Disuse States and Countermeasures on Muscle Molecular Signaling.

Autor: Sharlo K; Institute of Biomedical Problems RAS, Moscow 123007, Russia., Tyganov SA; Institute of Biomedical Problems RAS, Moscow 123007, Russia., Tomilovskaya E; Institute of Biomedical Problems RAS, Moscow 123007, Russia., Popov DV; Institute of Biomedical Problems RAS, Moscow 123007, Russia., Saveko AA; Institute of Biomedical Problems RAS, Moscow 123007, Russia., Shenkman BS; Institute of Biomedical Problems RAS, Moscow 123007, Russia.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2021 Dec 31; Vol. 23 (1). Date of Electronic Publication: 2021 Dec 31.
DOI: 10.3390/ijms23010468
Abstrakt: Skeletal muscle is capable of changing its structural parameters, metabolic rate and functional characteristics within a wide range when adapting to various loading regimens and states of the organism. Prolonged muscle inactivation leads to serious negative consequences that affect the quality of life and work capacity of people. This review examines various conditions that lead to decreased levels of muscle loading and activity and describes the key molecular mechanisms of muscle responses to these conditions. It also details the theoretical foundations of various methods preventing adverse muscle changes caused by decreased motor activity and describes these methods. A number of recent studies presented in this review make it possible to determine the molecular basis of the countermeasure methods used in rehabilitation and space medicine for many years, as well as to identify promising new approaches to rehabilitation and to form a holistic understanding of the mechanisms of gravity force control over the muscular system.
Databáze: MEDLINE
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