Prediction of Chemotoxicity, Unplanned Hospitalizations and Early Death in Older Patients with Colorectal Cancer Treated with Chemotherapy.

Autor: Feliu J; Oncology Department, La Paz University Hospital, IDIPAZ, CIBERONC, UAM-AMGEN Cathedra, 28046 Madrid, Spain., Espinosa E; Oncology Department, La Paz University Hospital, IDIPAZ, CIBERONC, UAM-AMGEN Cathedra, 28046 Madrid, Spain., Basterretxea L; Oncology Department, Donostia University Hospital, 20014 Donostia, Spain., Paredero I; Oncology Department, Doctor Peset University Hospital, 46017 Valencia, Spain., Llabrés E; Oncology Department, Insular University Hospital of Gran Canarias, 35016 Las Palmas, Spain., Jiménez-Munárriz B; Oncology Department, Centro Integral Oncológico Clara Campal, 28050 Madrid, Spain., Antonio-Rebollo M; Oncohematogeriatrics Unit, Institut Català d'Oncologia, IDIBELL Hospitalet, 08908 Barcelona, Spain., Losada B; Oncology Department, University Hospital of Fuenlabrada, 28942 Madrid, Spain., Pinto A; Oncology Department, La Paz University Hospital, IDIPAZ, CIBERONC, UAM-AMGEN Cathedra, 28046 Madrid, Spain., Custodio AB; Oncology Department, La Paz University Hospital, IDIPAZ, CIBERONC, UAM-AMGEN Cathedra, 28046 Madrid, Spain., Del Mar Muñoz M; Oncology Department, Hospital Virgen de la Luz, 16002 Cuenca, Spain., Gómez-Mediavilla J; Oncology Department, Donostia University Hospital, 20014 Donostia, Spain., Torregrosa MD; Oncology Department, Doctor Peset University Hospital, 46017 Valencia, Spain., Soler G; Oncohematogeriatrics Unit, Institut Català d'Oncologia, IDIBELL Hospitalet, 08908 Barcelona, Spain., Cruz P; Oncology Department, La Paz University Hospital, IDIPAZ, CIBERONC, UAM-AMGEN Cathedra, 28046 Madrid, Spain., Higuera O; Oncology Department, La Paz University Hospital, IDIPAZ, CIBERONC, UAM-AMGEN Cathedra, 28046 Madrid, Spain., Molina-Garrido MJ; Oncology Department, Hospital Virgen de la Luz, 16002 Cuenca, Spain.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2021 Dec 28; Vol. 14 (1). Date of Electronic Publication: 2021 Dec 28.
DOI: 10.3390/cancers14010127
Abstrakt: Purpose: To identify risk factors for toxicity, unplanned hospitalization (UH) and early death (ED) in older patients with colorectal carcinoma (CRC) initiating chemotherapy.
Methods: 215 patients over 70 years were prospectively included. Geriatric assessment was performed before treatment, and tumor and treatment variables were collected. The association between these factors and grade 3-5 toxicity, UH and ED (<6 months) was examined by using multivariable logistic regression. Score points were assigned to each risk factor.
Results: During the first 6 months of treatment, 33% of patients developed grade 3-5 toxicity, 31% had UH and 23% died. Risk factors were, for toxicity, instrumental activities of daily living, creatinine clearance, weight loss and MAX2 index; for UH, Charlson Comorbidity Score, creatinine clearance, weight loss, serum albumin, and metastatic disease; and for ED, basic activities in daily living, weight loss, metastatic disease, and hemoglobin levels. Predictive scores were built with these variables. The areas under receiver operation characteristic (ROC) curves for toxicity, UH and ED were 0.70 (95% CI: 0.64-0.766), 0.726 (95% IC: 0.661-0.799) and 0.74 (95% IC: 0.678-0.809), respectively.
Conclusion: Simple scores based on geriatric, tumor and laboratory characteristics predict severe toxicity, UH and ED, and may help in treatment planning.
Databáze: MEDLINE
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