Sarcopenia and Ghrelin System in the Clinical Outcome and Prognosis of Gastroenteropancreatic Neuroendocrine Neoplasms.

Autor: Herrera-Martínez Y; Department of Nuclear Medicine, Virgen del Rocio University Hospital, 41013 Seville, Spain., Alzas Teomiro C; Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, 14004 Cordova, Spain.; Endocrinology and Nutrition Service, Reina Sofia University Hospital, 14004 Cordova, Spain., León Idougourram S; Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, 14004 Cordova, Spain.; Endocrinology and Nutrition Service, Reina Sofia University Hospital, 14004 Cordova, Spain., Molina Puertas MJ; Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, 14004 Cordova, Spain.; Endocrinology and Nutrition Service, Reina Sofia University Hospital, 14004 Cordova, Spain., Calañas Continente A; Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, 14004 Cordova, Spain.; Endocrinology and Nutrition Service, Reina Sofia University Hospital, 14004 Cordova, Spain., Serrano Blanch R; Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, 14004 Cordova, Spain.; Medical Oncology Service, Reina Sofia University Hospital, 14004 Cordova, Spain., Castaño JP; Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, 14004 Cordova, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, 14014 Cordova, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 14004 Cordova, Spain., Gálvez Moreno MÁ; Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, 14004 Cordova, Spain.; Endocrinology and Nutrition Service, Reina Sofia University Hospital, 14004 Cordova, Spain., Gahete MD; Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, 14004 Cordova, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, 14014 Cordova, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 14004 Cordova, Spain., Luque RM; Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, 14004 Cordova, Spain.; Department of Cell Biology, Physiology, and Immunology, University of Córdoba, 14014 Cordova, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 14004 Cordova, Spain., Herrera-Martínez AD; Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, 14004 Cordova, Spain.; Endocrinology and Nutrition Service, Reina Sofia University Hospital, 14004 Cordova, Spain.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2021 Dec 27; Vol. 14 (1). Date of Electronic Publication: 2021 Dec 27.
DOI: 10.3390/cancers14010111
Abstrakt: Background: Malnutrition and sarcopenia affect clinical outcomes and treatment response in cancer patients. Patients with neuroendocrine neoplasms (NENs) may present with additional symptoms related to tumor localization in the gastrointestinal tract and hormone secretion, increasing the risk and effects of sarcopenia.
Aim: To explore the presence of malnutrition and sarcopenia in gastroenteropancreatic (GEP)-NEN patients, their relation to tumor characteristics, patient outcomes, survival and the molecular expression of ghrelin system components in the tumor.
Patients and Methods: One-hundred-and-four patients were included. Anthropometric, biochemical and CT-scans at diagnosis were evaluated. The expression levels of key ghrelin system components were assessed in 63 tumor samples.
Results: Nutritional parameters were similar in GEP-NEN tumors of different origin. Relapsed disease was associated with decreased BMI. Patients who presented with weight loss at diagnosis had significantly lower overall survival (108 (25-302) vs. 263 (79-136) months). Ghrelin O-acyltransferase (GOAT) enzyme expression was higher in these patients. The prevalence of sarcopenia using CT images reached 87.2%. Mortality was observed only in patients with sarcopenia. Muscle evaluation was correlated with biochemical parameters but not with the expression of ghrelin system components.
Conclusion: Survival is related to the nutritional status of patients with GEP-NENs and also to the molecular expression of some relevant ghrelin system components. Routine nutritional evaluation should be performed in these patients, in order to prescribe appropriate nutritional support, when necessary, for increasing quality of life and improving clinical outcomes.
Databáze: MEDLINE
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