Th17/Regulatory T cells ratio evolution: A prospective study in a group of healthy pregnant women.

Autor: Braga A; Obstetrics Department, Centro Materno Infantil do Norte, Centro Hospitalar Universitário do Porto, Oporto, Portugal; Instituto Ciências Biomédicas Abel Salazar, Oporto University, Oporto, Portugal. Electronic address: ajcbraga2@gmail.com., Neves E; Instituto Ciências Biomédicas Abel Salazar, Oporto University, Oporto, Portugal; Immunology Department, Centro Hospitalar Universitário do Porto, Oporto, Portugal., Guimarães J; Immunology Department, Centro Hospitalar Universitário do Porto, Oporto, Portugal., Braga J; Obstetrics Department, Centro Materno Infantil do Norte, Centro Hospitalar Universitário do Porto, Oporto, Portugal; Instituto Ciências Biomédicas Abel Salazar, Oporto University, Oporto, Portugal., Vasconcelos C; Instituto Ciências Biomédicas Abel Salazar, Oporto University, Oporto, Portugal; Clinical Immunology Unit, Centro Hospitalar Universitário do Porto, Oporto, Portugal.
Jazyk: angličtina
Zdroj: Journal of reproductive immunology [J Reprod Immunol] 2022 Feb; Vol. 149, pp. 103468. Date of Electronic Publication: 2021 Dec 24.
DOI: 10.1016/j.jri.2021.103468
Abstrakt: During pregnancy, the maternal immune system is challenged to tolerate a semi-allogenic fetus. A shift toward a tolerogenic profile is essential to ensure a healthy fetal and placental development. One of the most important mechanisms involved in the maternal immune tolerance towards the fetal antigens is expressed in the activity of the regulatory T (Treg) and Th17 cells. The behavior and equilibrium of these two T lymphocyte populations were rarely studied in normal healthy pregnancies through the beginning of gestation to the postpartum period. We conducted a prospective longitudinal observational study where peripheral blood lymphocyte subsets were analyzed in each trimester of pregnancy and postpartum period in a group of healthy pregnant women. Our study observed a consistent reduction in peripheric Treg cell count through all pregnancy while the Th17 cell count remained stable. The Th17/Treg ratio increases significantly throughout pregnancy to the postpartum period. These changes could be justified by the migration of the immunotolerant Treg cells to the maternal decidua and lead to the establishment of a systemic pro-inflammatory profile by the end of pregnancy. This data could explain why systemic syndromes like preeclampsia develop in susceptible women during the second half of pregnancy or why many autoimmune disorders flourish in the first weeks postpartum.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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