Fibrous Scaffolds for Muscle Tissue Engineering Based on Touch-Spun Poly(Ester-Urethane) Elastomer.

Autor: Uribe-Gomez J; Faculty of Engineering Sciences and Bavarian Polymer Institute, University of Bayreuth, Ludwig Thoma Str. 36A, Bayreuth, 95447, Germany., Schönfeld D; Fraunhofer Institute for Applied Polymer Research IAP, Geiselbergstr. 69, Potsdam, 14476, Germany., Posada-Murcia A; Faculty of Engineering Sciences and Bavarian Polymer Institute, University of Bayreuth, Ludwig Thoma Str. 36A, Bayreuth, 95447, Germany., Roland MM; Faculty of Engineering Sciences and Bavarian Polymer Institute, University of Bayreuth, Ludwig Thoma Str. 36A, Bayreuth, 95447, Germany., Caspari A; Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, Dresden, 01069, Germany., Synytska A; Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, Dresden, 01069, Germany.; Fakultät Mathematik und Naturwissenschaften, Technische Universität Dresden, Mommsenstrasse 4, Dresden, 01064, Germany.; Bayerisches Polymerinstitut - BPI, Universität Bayreuth, Universitätsstraße 30, Bayreuth, 95440, Germany., Salehi S; Department of Biomaterials, University of Bayreuth, Prof.-Rüdiger-Bormann Str. 1, Bayreuth, 95447, Germany., Pretsch T; Fraunhofer Institute for Applied Polymer Research IAP, Geiselbergstr. 69, Potsdam, 14476, Germany., Ionov L; Faculty of Engineering Sciences and Bavarian Polymer Institute, University of Bayreuth, Ludwig Thoma Str. 36A, Bayreuth, 95447, Germany.
Jazyk: angličtina
Zdroj: Macromolecular bioscience [Macromol Biosci] 2022 Apr; Vol. 22 (4), pp. e2100427. Date of Electronic Publication: 2022 Jan 17.
DOI: 10.1002/mabi.202100427
Abstrakt: Development of fiber-spinning technologies and materials with proper mechanical properties is highly important for the manufacturing of aligned fibrous scaffolds mimicking structure of the muscle tissues. Here, the authors report touch spinning of a thermoplastic poly(1,4-butylene adipate)-based polyurethane elastomer, obtained via solvent-free polymerization. This polymer possesses a combination of important advantages such as 1) low elastic modulus in the range of a few MPa, 2) good recovery ratio and 3) resilience, 4) processability, 5) nontoxicity, 6) biocompatibility, and 7) biodegradability that makes it suitable for fabrication of structures mimicking extracellular matrix of muscle tissue. Touch spinning allows fast and precise deposition of highly aligned micro- and nano-fibers without use of high voltage. C2C12 myoblasts readily align along soft polymer fibers and demonstrate high viability as well as proliferation that make proposed combination of polymer and fabrication method highly suitable for engineering skeletal muscles.
(© 2022 Wiley-VCH GmbH.)
Databáze: MEDLINE
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