aEEG vs cEEG's sensivity for seizure detection in the setting of neonatal intensive care units: A systematic review and meta-analysis.

Autor: Falsaperla R; Unit of Neonatology, University Hospital 'Policlinico - San Marco', Catania, Italy., Scalia B; Unit of Neonatology, University Hospital 'Policlinico - San Marco', Catania, Italy., Giaccone F; Pediatrics Postgraduate Program, Section of Pediatrics and Child Neuropsychiatry, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy., Suppiej A; Department of Medical Sciences, Pediatric Section, University of Ferrara, Ferrara, Italy., Pulvirenti A; Bioinformatics Unit, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy., Mailo J; Division of Pediatric Neurology, University of Alberta, Edmonton, Canada., Ruggieri M; Unit of Rare Diseases of the Nervous System, Section of Pediatrics and Child Neuropsychiatry, A.U.O. Policlinico-Vittorio Emanuele Catania, Catania, Italy.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2022 May; Vol. 111 (5), pp. 916-926. Date of Electronic Publication: 2022 Feb 16.
DOI: 10.1111/apa.16251
Abstrakt: Aim: Amplitude-integrated electroencephalography (aEEG)'s accuracy compared to conventional electroencephalography (cEEG) has not been fully established. The aim of our study was to conduct a systematic review on the sensitivity of the aEEG for neonatal seizure detection.
Methods: Studies from PubMed and Google Scholar databases comparing recordings of cEEG and aEEG in newborns were included according to the PRISMA method. A quality assessment using the QUADAS-2 tool was provided. A random-effect model was used to account for different sources of variations among studies. Publication biases were represented by a funnel plot, and funnel plot symmetry was assessed.
Results: Fourteen studies were reported; sensitivity of each diagnostic tool used (single-channel aEEG, two-channel aEEG, two-channel aEEG plus raw trace EEG) was compared to that of the gold-standard cEEG and to those of the other methods used. Overall sensitivity of the aEEG ranged from 31.25% to 90%.
Conclusion: Our study provides evidence that sensitivity of aEEG varies significantly and that seizure detection rate is lower than that of cEEG. The two-channel aEEG with raw trace EEG shows a high sensitivity and might represent a valid alternative to the cEEG in the setting of neonatal intensive care units (NICUs).
(© 2022 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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