Turmeric extract alleviates endocrine-metabolic disturbances in letrozole-induced PCOS by increasing adiponectin circulation: A comparison with Metformin.

Autor:	Shah MZUH; Laboratory of Endocrinology, Department of Bioscience, Barkatullah University, Bhopal, India., Shrivastava VK; Laboratory of Endocrinology, Department of Bioscience, Barkatullah University, Bhopal, India.
Jazyk:	angličtina
Zdroj:	Metabolism open [Metabol Open] 2021 Dec 20; Vol. 13, pp. 100160. Date of Electronic Publication: 2021 Dec 20 (Print Publication: 2022).
DOI:	10.1016/j.metop.2021.100160
Abstrakt:	One of the most common causes of female infertility is polycystic ovarian syndrome, which affects 6-21% of the population. Regrettably, the currently available treatments are mostly symptomatic and ineffective. As a result, safer options are needed now more than ever. In a letrozole PCOS albino mouse model, the current study compares the therapeutic advantages of Turmeric extract (Curcuma longa) to metformin. Adiponectin is a circulating protein generated by adipocytes that has been linked to metabolic diseases (MDs) in an inverse relationship. The effects of Turmeric Extract (Curcuma Longa) in contrast to Metformin, as well as the involvement of adiponectin in endocrine-metabolic abnormalities in experimentally induced PCOS mice model, were studied in this study. Letrozole (6 mg/kg) was administered orally (p.o) for 21 days to induce PCOS, followed by a dose of Turmeric Extract (Curcuma longa) (175 mg/kg and p.o) and Metformin (150 mg/kg) for 30 days, both with normal saline water (0.9%) as the carrier. The findings revealed that LET-treated mice displayed PCOS-like characteristics, such as higher LH levels, increased body weight growth, and ovarian morphology with numerous cysts, increase in fasting blood glucose, lipid profile, plasma lipid peroxidation (MDA) and IL-6, as well as a decrease in serum Progesterone, Estrogen, FSH, SOD and GSH levels in the ovary. These changes were linked to lower levels of circulating adiponectin and were reversed when treated Turmeric extract. By altering circulating androgen-adiponectin balance, the data implies that Turmeric extract alleviates endocrine-metabolic abnormalities and inflammation-related comorbidities associated with LET-induced PCOS. (© 2021 The Author(s).)
Databáze:	MEDLINE
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