The evolution of knowledge on genes associated with human diseases.

Autor:	Lüscher-Dias T; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Siqueira Dalmolin RJ; Bioinformatics Multidisciplinary Environment-BioME, IMD, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Department of Biochemistry, CB, Federal University of Rio Grande do Norte, Natal, RN, Brazil., de Paiva Amaral P; Instituto de Ensino e Pesquisa, Insper, São Paulo, Brazil., Alves TL; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Schuch V; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Franco GR; Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Nakaya HI; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.; Scientific Platform Pasteur-University of São Paulo, São Paulo, Brazil.; Hospital Israelita Albert Einstein, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2021 Dec 11; Vol. 25 (1), pp. 103610. Date of Electronic Publication: 2021 Dec 11 (Print Publication: 2022).
DOI:	10.1016/j.isci.2021.103610
Abstrakt:	Thousands of biomedical scientific articles, including those describing genes associated with human diseases, are published every week. Computational methods such as text mining and machine learning algorithms are now able to automatically detect these associations. In this study, we used a cognitive computing text-mining application to construct a knowledge network comprising 3,723 genes and 99 diseases. We then tracked the yearly changes on these networks to analyze how our knowledge has evolved in the past 30 years. Our systems approach helped to unravel the molecular bases of diseases and detect shared mechanisms between clinically distinct diseases. It also revealed that multi-purpose therapeutic drugs target genes that are commonly associated with several psychiatric, inflammatory, or infectious disorders. By navigating this knowledge tsunami, we were able to extract relevant biological information and insights about human diseases. Competing Interests: The authors declare no competing interests. (© 2021 The Author(s).)
Databáze:	MEDLINE
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