Single-Center Study of 103 Consecutive Parkinson's Disease Patients with Levodopa-Carbidopa Intestinal Gel.

Autor: Viljaharju V; Department of Neurology Helsinki University Hospital Helsinki Finland.; Department of Clinical Neurosciences (Neurology) University of Helsinki Helsinki Finland., Mertsalmi T; Department of Neurology Helsinki University Hospital Helsinki Finland.; Department of Clinical Neurosciences (Neurology) University of Helsinki Helsinki Finland., Pauls KAM; Department of Neurology Helsinki University Hospital Helsinki Finland.; Department of Clinical Neurosciences (Neurology) University of Helsinki Helsinki Finland., Koivu M; Department of Neurology Helsinki University Hospital Helsinki Finland.; Department of Clinical Neurosciences (Neurology) University of Helsinki Helsinki Finland., Eerola-Rautio J; Department of Neurology Helsinki University Hospital Helsinki Finland.; Department of Clinical Neurosciences (Neurology) University of Helsinki Helsinki Finland., Udd M; Department of Gastroenterological Surgery Helsinki University Hospital Helsinki Finland., Pekkonen E; Department of Neurology Helsinki University Hospital Helsinki Finland.; Department of Clinical Neurosciences (Neurology) University of Helsinki Helsinki Finland.
Jazyk: angličtina
Zdroj: Movement disorders clinical practice [Mov Disord Clin Pract] 2021 Nov 04; Vol. 9 (1), pp. 60-68. Date of Electronic Publication: 2021 Nov 04 (Print Publication: 2022).
DOI: 10.1002/mdc3.13361
Abstrakt: Background: Levodopa-carbidopa intestinal gel (LCIG) effectively reduces off time and dyskinesia and increases on time in advanced Parkinson's disease (PD). However, patients with LCIG-infusion experience frequent complications and some discontinue treatment early on.
Objectives: The objectives of this study were to find predictive factors for early dropout from the LCIG infusion, analyze the treatment burden on the tertiary health care system, and explore changes in medication during the LCIG treatment.
Methods: LCIG-infusion was administrated to 103 patients between July 2006 and May 2020 at the Helsinki University Hospital, accumulating 350 years of follow-up data. We evaluated, retrospectively, changes in medication during treatment, discontinuation of the infusion, and adverse events from the patient records.
Results: Living alone was a predictive factor for early dropout (OR = 3.88; 95% CI = 1.03-14.66; P  = 0.045). The treatment burden on the tertiary health care system increased after the initiation of LCIG infusion mostly because of common complications related to the infusion system (median change of in- and out-patient visits +1, P  = 0.03). Mean levodopa equivalent daily dose (LEDD) rose from baseline to 6 months (1246.7 vs. 1684.9, P  = 0.001) and stabilized thereafter. Patients commonly switched from "polypharmacy" to "LCIG-only" or "LCIG + oral levodopa" medication-groups during long-term treatment.
Conclusions: Recurrent complications related to the infusion system increase the treatment burden on tertiary healthcare system after the initiation of LCIG-infusion. Most patients continue long-term with the infusion. Few patients discontinue infusion during the first year after initiation and living alone appears to be a risk factor for this outcome.
(© 2021 International Parkinson and Movement Disorder Society.)
Databáze: MEDLINE
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