Characterization of multi-biomarkers for bone health assessment based on photoacoustic physicochemical analysis method.

Autor:	Feng T; School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China., Xie Y; School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China., Xie W; Institute of Acoustics, School of Physics Science and Engineering, Tongji University, Shanghai 200092, China., Chen Y; Institute of Acoustics, School of Physics Science and Engineering, Tongji University, Shanghai 200092, China., Wang P; Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210008, Jiangsu, China., Li L; Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210008, Jiangsu, China., Han J; School of Electronic and Optical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China., Ta D; Department of Electronic Engineering, Fudan University, Shanghai 200433, China., Cheng L; The Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Department of Orthopaedics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China., Cheng Q; Institute of Acoustics, School of Physics Science and Engineering, Tongji University, Shanghai 200092, China.; The Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration, Ministry of Education, Department of Orthopaedics, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, China.
Jazyk:	angličtina
Zdroj:	Photoacoustics [Photoacoustics] 2021 Dec 14; Vol. 25, pp. 100320. Date of Electronic Publication: 2021 Dec 14 (Print Publication: 2022).
DOI:	10.1016/j.pacs.2021.100320
Abstrakt:	Photoacoustic (PA) techniques are potential alternatives to histopathology. The physicochemical spectrogram (PCS) generated by the PA measurement at multiple wavelengths can presents the morphology and chemical composition target at multi-biomarkers simultaneously. In this work, via multi-wavelength PA measurements performed on rabbit bone models, we investigated the feasibility of using PCSs for bone health assessment. A comprehensive analysis of the PCSs, termed PA physicochemical analysis (PAPCA), was conducted. The " slope " and " relative content " were used as the PAPCA-quantified parameters to characterize the changes in the physical and chemical properties of bone tissue, respectively. The findings are consistent well with the gold-standard imaging results. It demonstrated that the PAPCA can be used to characterize both the microstructure and content of multi-biomarkers which highly related with bone health. Considering the PA technique is noninvasive and radiation-free, it has great potential in the implementation and monitoring of bone diseases progression. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2021 The Authors. Published by Elsevier GmbH.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu