Potential benefit of olive leaf extract in cervical spondylotic myelopathy model.

Autor:	Ibrahim S; Department of Neurosurgery, Medical Faculty Universitas Sumatera Utara, Medan, Indonesia., Adeputra Nasution IF; Department of General Surgery, Medical Faculty Universitas Sumatera Utara, Medan, Indonesia., Danil M; Department of Neurosurgery, Medical Faculty Universitas Sumatera Utara, Medan, Indonesia., Sadewo W; Department of Neurosurgery, Universitas Indonesia, Jakarta, Indonesia., Widyawati T; Department of Pharmacology and Therapeutic, Medical Faculty Universitas Sumatera Utara, Medan, Indonesia., Eyanoer PC; Department of Community Health Program, Medical Faculty Universitas Sumatera Utara, Medan, Indonesia., Ritarwan K; Department of Neurology, Medical Faculty Universitas Sumatera Utara, Medan, Indonesia., Riawan W; Department of Biochemistry and Biology Molecular, Medical Faculty Universitas Brawijaya, Malang, Indonesia., Darmajaya R; Department of Neurosurgery, Medical Faculty Universitas Sumatera Utara, Medan, Indonesia.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2021 Nov 11; Vol. 73, pp. 103040. Date of Electronic Publication: 2021 Nov 11 (Print Publication: 2022).
DOI:	10.1016/j.amsu.2021.103040
Abstrakt:	Introduction: Cervical spondylosis is the most common cause of myelopathy in the cervical due to chronic compression of the spinal cord in patients aged 55 years or older. Recent studies suggest that olive extracts suppress inflammation and reduce stress oxidative injury. The purpose of this study was to determine the potential neuroprotective effects of olive leaf extract (OLE) in an experimental cervical spondylotic myelopathy model. Methods: This study was divided into 6 groups; Control Negative (Sham-Operated) Group, Control Positive 1 & 2 (early chronic and chronic), Treatment Groups 1, 2 & 3 (prophylactic, concomitant & late). Olive leaf extract (OLE) give 350 mg/kg BW and spinal cord sample was taken at the compression level C5. Histopathological assessment and immunohistochemistry of Amyloid-β, p-Tau, TDP-43 dan CD-68 dan evaluation of functional motoric outcome was done before animals were terminated. Results: Chronic spinal cord compression increased the expression of Amyloid-β, p-Tau, TDP-43 dan CD-68. OLE 350 mg/kg BW decreased the expression of these biomarkers and increased functional motoric outcome, especially as prophylactic dan concomitant treatment. Discussion: These findings indicate that OLE may be effective in protecting cervical spondylotic myelopathy. Competing Interests: Not Applicable. (© 2021 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd.)
Databáze:	MEDLINE
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