Antihypertensive and cardioprotective effects of different monotherapies and combination therapies in young spontaneously hypertensive rats - A pilot study.
| Autor: | Hawlitschek C; University of Leipzig, Faculty of Medicine, Carl-Ludwig-Institute of Physiology, Liebigstrasse 27, Leipzig, Germany., Brendel J; University of Leipzig, Faculty of Medicine, Carl-Ludwig-Institute of Physiology, Liebigstrasse 27, Leipzig, Germany., Gabriel P; University of Leipzig, Faculty of Medicine, Carl-Ludwig-Institute of Physiology, Liebigstrasse 27, Leipzig, Germany., Schierle K; University of Leipzig, Faculty of Medicine, Institute of Pathology, Liebigstrasse 26, Leipzig, Germany., Salameh A; University of Leipzig, Faculty of Medicine, Heart Centre, Department of Pediatric Cardiology, Strümpellstrasse 39, Leipzig, Germany., Zimmer HG; University of Leipzig, Faculty of Medicine, Carl-Ludwig-Institute of Physiology, Liebigstrasse 27, Leipzig, Germany., Rassler B; University of Leipzig, Faculty of Medicine, Carl-Ludwig-Institute of Physiology, Liebigstrasse 27, Leipzig, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | Saudi journal of biological sciences [Saudi J Biol Sci] 2022 Jan; Vol. 29 (1), pp. 339-345. Date of Electronic Publication: 2021 Sep 08. |
| DOI: | 10.1016/j.sjbs.2021.08.093 |
| Abstrakt: | Spontaneously hypertensive rats (SHR) are an established animal model for antihypertensive treatment. The aim of this pilot study was a systematic search for two lines of antihypertensive treatment - a monotherapy and a combination of two drugs - to be applied in a future study on old SHR. Originally, representatives of three drug classes recommended for antihypertensive therapy in humans should be applied, namely captopril (CAP) as an antagonist of the renin-angiotensin-aldosterone system, nifedipine (NIF) as calcium channel blocker and propranolol (PROP) as β-adrenergic blocker. As we observed that PROP had been poorly ingested, all groups with PROP therapy were excluded from the study. CAP (60 mg kg -1 d -1 ), NIF (10 mg kg -1 d -1 ) or both were administered orally to seven-week-old SHR over 3 weeks. A further group of SHR received no treatment (SHR/CTRL). Age-matched normotensive Wistar-Kyoto rats served as normotensive controls. We examined the effect of the antihypertensive therapies on systolic blood pressure, heart weight and on histological and biochemical markers of cardiac hypertrophy and fibrosis. CAP proved to be the most effective treatment reducing blood pressure and relative heart weight significantly compared to SHR/CTRL without reaching normotensive values. Beginning cardiac fibrosis observed in SHR/CTRL was completely abrogated with CAP treatment. Similar effects were achieved with a combination of CAP and NIF. CAP as monotherapy and CAP + NIF as combination therapy were chosen for the forthcoming study on old SHR. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2021 The Author(s).) |
| Databáze: | MEDLINE |
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