Effect of kolaviron on islet dynamics in diabetic rats.

Autor:	Oyenihi OR; Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7535, South Africa., Cerf ME; Grants, Innovation and Product Development, South African Medical Research Council, Tygerberg, South Africa.; Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg, South Africa., Matsabisa MG; Pharmacology Department, School of Clinical Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein, South Africa., Brooks NL; Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa., Oguntibeju OO; Phytomedicine and Phytochemistry Group, Department of Biomedical Sciences, Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Bellville 7535, South Africa.
Jazyk:	angličtina
Zdroj:	Saudi journal of biological sciences [Saudi J Biol Sci] 2022 Jan; Vol. 29 (1), pp. 324-330. Date of Electronic Publication: 2021 Sep 06.
DOI:	10.1016/j.sjbs.2021.08.095
Abstrakt:	Kolaviron, a biflavonoid isolated from the edible seeds of Garcinia kola , lowers blood glucose in experimental models of diabetes; however, the underlying mechanisms are not yet fully elucidated. The objective of the current study was to assess the effects of kolaviron on islet dynamics in streptozotocin-induced diabetic rats. Using double immunolabeling of glucagon and insulin, we identified insulin-producing β- and glucagon-producing α-cells in the islets of diabetic and control rats and determined the fractional β-cell area, α-cell area and islet number. STZ challenged rats presented with islet hypoplasia and reduced β-cell area concomitant with an increase in α-cell area. Kolaviron restored some islet architecture in diabetic rats through the increased β-cell area. Overall, kolaviron-treated diabetic rats presented a significant (p < 0.05) increase in the number of large and very large islets compared to diabetic control but no difference in islet number and α-cell area. The β-cell replenishment potential of kolaviron and its overall positive effects on glycemic control suggest that it may be a viable target for diabetes treatment. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2021 The Author(s).)
Databáze:	MEDLINE
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