Utility of the Repeat and Point Test for Subtyping Patients With Primary Progressive Aphasia.

Autor:	Seckin M; Neurologische Klinik und Poliklinik.; Acibadem Mehmet Ali Aydinlar University School of Medicine, Department of Neurology, İstanbul, Turkey., Ricard I; Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Unversität München., Raiser T; Neurologische Klinik und Poliklinik., Heitkamp N; Neurologische Klinik und Poliklinik., Ebert A; Neurologische Klinik, Universitätsmedizin Mannheim, Mannheim., Prix C; Neurologische Klinik und Poliklinik., Levin J; Neurologische Klinik und Poliklinik.; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE).; Munich Cluster for Systems Neurology (SyNergy)., Diehl-Schmid J; Department of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, Munich., Riedl L; Department of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, Munich., Roßmeier C; Department of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, Munich., Hoen N; Department of Psychiatry and Psychotherapy, School of Medicine, Technical University of Munich, Munich., Schroeter ML; Max Planck Institute for Human Cognitive and Brain Sciences, Neurology, and Clinic for Cognitive Neurology, University Hospital Leipzig, Leipzig., Marschhauser A; Max Planck Institute for Human Cognitive and Brain Sciences, Neurology, and Clinic for Cognitive Neurology, University Hospital Leipzig, Leipzig., Obrig H; Max Planck Institute for Human Cognitive and Brain Sciences, Neurology, and Clinic for Cognitive Neurology, University Hospital Leipzig, Leipzig., Benke T; Universitätsklinik für Neurologie, Kognitive Neurologie und Neuropsychologie, Innsbruck, Austria., Kornhuber J; Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Erlangen., Fliessbach K; Klinik für Neurodegenerative Erkrankungen und Gerontopsychiatrie, Universitätsklinikum Bonn & Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn., Schneider A; Klinik für Neurodegenerative Erkrankungen und Gerontopsychiatrie, Universitätsklinikum Bonn & Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn., Wiltfang J; Klinik für Psychiatrie und Psychotherapie, Universitätsmedizin Göttingen, Göttingen., Jahn H; Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Hamburg-Eppendorf, Hamburg., Fassbender K; Neurologische Klinik und Poliklinik, Universität des Saarlandes, KirrbergerStraße, Homburg., Prudlo J; Klinik für Neurologie und Poliklinik, Universitätsklinikum Rostock, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Rostock., Lauer M; Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie, Universität Würzburg, Würzburg., Duning T; Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Westfälische-Wilhelms-Universität, Münster., Wilke C; Department of Neurodegenerative Diseases, Centre for Neurology and Hertie-Institute for Clinical Brain Research, University Hospital.; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Tübingen., Synofzik M; Department of Neurodegenerative Diseases, Centre for Neurology and Hertie-Institute for Clinical Brain Research, University Hospital.; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Tübingen., Anderl-Straub S; Neurologische Klinik und Poliklinik, Universität Ulm., Semler E; Neurologische Klinik und Poliklinik, Universität Ulm., Lombardi J; Neurologische Klinik und Poliklinik, Universität Ulm., Landwehrmeyer B; Neurologische Klinik und Poliklinik, Universität Ulm., Ludolph A; Neurologische Klinik und Poliklinik, Universität Ulm.; Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Ulm., Otto M; Neurologische Klinik und Poliklinik, Universität Ulm., Danek A; Neurologische Klinik und Poliklinik.
Jazyk:	angličtina
Zdroj:	Alzheimer disease and associated disorders [Alzheimer Dis Assoc Disord] 2022 Jan-Mar 01; Vol. 36 (1), pp. 44-51.
DOI:	10.1097/WAD.0000000000000482
Abstrakt:	Background: Primary progressive aphasia (PPA) may present with three distinct clinical sybtypes: semantic variant PPA (svPPA), nonfluent/agrammatic variant PPA (nfvPPA), and logopenic variant PPA (lvPPA). Objective: The aim was to examine the utility of the German version of the Repeat and Point (R&P) Test for subtyping patients with PPA. Method: During the R&P Test, the examiner reads out aloud a noun and the participants are asked to repeat the word and subsequently point to the corresponding picture. Data from 204 patients (68 svPPA, 85 nfvPPA, and 51 lvPPA) and 33 healthy controls were analyzed. Results: Controls completed both tasks with >90% accuracy. Patients with svPPA had high scores in repetition (mean=9.2±1.32) but low scores in pointing (mean=6±2.52). In contrast, patients with nfvPPA and lvPPA performed comparably in both tasks with lower scores in repetition (mean=7.4±2.7 for nfvPPA and 8.2±2.34 for lvPPA) but higher scores in pointing (mean=8.9±1.41 for nfvPPA and 8.6±1.62 for lvPPA). The R&P Test had high accuracy discriminating svPPA from nfvPPA (83% accuracy) and lvPPA (79% accuracy). However, there was low accuracy discriminating nfvPPA from lvPPA (<60%). Conclusion: The R&P Test helps to differentiate svPPA from 2 nonsemantic variants (nfvPPA and lvPPA). However, additional tests are required for the differentiation of nfvPPA and lvPPA. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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