Low-dimensional compounds containing bioactive ligands. Part XVII: Synthesis, structural, spectral and biological properties of hybrid organic-inorganic complexes based on [PdCl 4 ] 2- with derivatives of 8-hydroxyquinolinium.

Autor: Drweesh EA; Department of Inorganic Chemistry, National Research Centre, 33 Elbohoth St. (former Eltahrir st.), P.O. 12622, Dokki, Giza, Egypt., Kuchárová V; Institute of Experimental Physics SAS, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia., Volarevic V; Faculty of Medical Sciences University of Kragujevac, 69 Svetozara Markovica, 34000 Kragujevac, Serbia., Miloradovic D; Faculty of Medical Sciences University of Kragujevac, 69 Svetozara Markovica, 34000 Kragujevac, Serbia., Ilic A; Faculty of Medical Sciences University of Kragujevac, 69 Svetozara Markovica, 34000 Kragujevac, Serbia., Radojević ID; Department of Biology and Ecology, Faculty of Science, University of Kragujevac, Radoja Domanovića 12, 34000 Kragujevac, Serbia., Raković IR; Faculty of Medical Sciences University of Kragujevac, 69 Svetozara Markovica, 34000 Kragujevac, Serbia., Smolková R; Department of Ecology, Faculty of Humanities and Natural Sciences, University of Prešov, Ulica 17. novembra 1, 081 16 Prešov, Slovakia., Vilková M; Institute of Chemistry, P. J. Šafárik University in Košice, Moyzesova 11, 041 54 Košice, Slovakia., Sabolová D; Institute of Chemistry, P. J. Šafárik University in Košice, Moyzesova 11, 041 54 Košice, Slovakia., Elnagar MM; Department of Inorganic Chemistry, National Research Centre, 33 Elbohoth St. (former Eltahrir st.), P.O. 12622, Dokki, Giza, Egypt., Potočňák I; Institute of Chemistry, P. J. Šafárik University in Košice, Moyzesova 11, 041 54 Košice, Slovakia. Electronic address: ivan.potocnak@upjs.sk.
Jazyk: angličtina
Zdroj: Journal of inorganic biochemistry [J Inorg Biochem] 2022 Mar; Vol. 228, pp. 111697. Date of Electronic Publication: 2021 Dec 30.
DOI: 10.1016/j.jinorgbio.2021.111697
Abstrakt: In this study, four hybrid organic-inorganic compounds (8-H 2 Q) 2 [PdCl 4 ] (1), (H 2 ClQ) 2 [PdCl 4 ] (2), (H 2 NQ) 2 [PdCl 4 ] (3) and (H 2 MeQ) 2 [PdCl 4 ]·2H 2 O (4) (where 8-H 2 Q = 8-hydroxyquinolinium, H 2 ClQ = 5-chloro-8-hydroxyquinolinium, H 2 NQ = 5-nitro-8-hydroxyquinolinium and H 2 MeQ = 2-methyl-8-hydroxyquinolinium) were synthesized through organic cation modulation. Single-crystal X-ray structure analysis of compounds 1 and 3 indicates that their structures are planar and consist of [PdCl 4 ] 2- anions and 8-H 2 Q or H 2 NQ cations, respectively. Both ionic components are held together through ionic interactions and hydrogen bonds forming infinite chains linked through π-π interactions to form 2D structures. Furthermore, NMR spectroscopy, UV-Vis spectroscopy, elemental analysis, and FT-IR spectroscopy were used to explore the synthesized compounds. The DNA interaction, antimicrobial activity, antiproliferative activity, and radical scavenging effect of the compounds were evaluated. The hybrid compounds and their free ligands can interact with the calf thymus DNA via an intercalation mode involving the insertion of the aromatic chromophore between the base pairs of DNA; compound 1 has the highest binding affinity. Moreover, they have high antimicrobial efficacy against the tested 14 strains of microorganisms with minimum inhibitory concentration values ranging from <1.95 to 250 μg/mL. The antiproliferative activity of the compounds was investigated against three different cancer cell lines, and their selectivity was verified on mesenchymal stem cells. Compounds 1 and 2 displayed selective and high cytotoxicity against human lung and breast cancer cells and showed moderate cytotoxicity against colon cancer cells. Accordingly, they might be auspicious candidates for future pharmacological investigations in lung and breast cancer research.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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