Cortical thickness across the cingulate gyrus in schizophrenia and its association to illness duration and memory performance.

Autor: Thielen JW; Department of Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Duisburg, Germany. jan-willem.thielen@uni-due.de., Müller BW; Department of Psychiatry and Psychotherapy, LVR-Hospital Essen, Faculty of Medicine, University of Duisburg-Essen, Duisburg, Germany.; Department of Psychology, University of Wuppertal, Wuppertal, Germany., Chang DI; Department of Psychiatry, LWL University Hospital Bochum, Ruhr University Bochum, Bochum, Germany., Krug A; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Mehl S; Department of Psychiatry and Psychotherapy and Center for Mind, Brain and Behavior (MCMBB), Philipps-University, Marburg, Germany., Rapp A; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Walter H; Division of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany., Winterer G; Department of Psychiatry and Psychotherapy, University of Berlin, Berlin, Germany., Vogeley K; Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.; Institute of Neuroscience and Medicine, Cognitive Neuroscience (INM-3), Research Center Jülich, Jülich, Germany., Klingberg S; Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany., Wagner M; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Kircher T; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Jazyk: angličtina
Zdroj: European archives of psychiatry and clinical neuroscience [Eur Arch Psychiatry Clin Neurosci] 2022 Oct; Vol. 272 (7), pp. 1241-1251. Date of Electronic Publication: 2022 Jan 08.
DOI: 10.1007/s00406-021-01369-2
Abstrakt: Schizophrenia has been associated with structural brain abnormalities and cognitive deficits that partly change during the course of illness. In the present study, cortical thickness in five subregions of the cingulate gyrus was assessed in 44 patients with schizophrenia-spectrum disorder and 47 control persons and related to illness duration and memory capacities. In the patients group, cortical thickness was increased in the posterior part of the cingulate gyrus and related to illness duration whereas cortical thickness was decreased in anterior parts unrelated to illness duration. In contrast, cortical thickness was related to episodic and working memory performance only in the anterior but not posterior parts of the cingulate gyrus. Our finding of a posterior cingulate increase may point to either increased parietal communication that is accompanied by augmented neural plasticity or to effects of altered neurodegenerative processes in schizophrenia.
(© 2022. The Author(s).)
Databáze: MEDLINE
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