Correlation between gene expression and MRI STIR signals in patients with chronic low back pain and Modic changes indicates immune involvement.

Autor: Vigeland MD; Division of Clinical Neuroscience, Department of Research, Innovation and Education, Oslo University Hospital, Oslo, Norway. mariadvi@uio.no.; Faculty of Medicine, University of Oslo, Oslo, Norway. mariadvi@uio.no., Flåm ST; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., Vigeland MD; Faculty of Medicine, University of Oslo, Oslo, Norway.; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway., Espeland A; Department of Radiology, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway., Kristoffersen PM; Department of Radiology, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway., Vetti N; Department of Radiology, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway., Wigemyr M; Division of Clinical Neuroscience, Department of Research, Innovation and Education, Oslo University Hospital, Oslo, Norway., Bråten LCH; Division of Clinical Neuroscience, Department of Research, Innovation and Education, Oslo University Hospital, Oslo, Norway., Gjefsen E; Division of Clinical Neuroscience, Department of Research, Innovation and Education, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway., Schistad EI; Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway., Haugen AJ; Department of Rheumatology, Østfold Hospital Trust, Grålum, Norway., Froholdt A; Department of Physical Medicine and Rehabilitation, Drammen Hospital, Drammen, Norway., Skouen JS; Department of Physical Medicine and Rehabilitation, Haukeland University Hospital, Bergen, Norway.; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway., Zwart JA; Division of Clinical Neuroscience, Department of Research, Innovation and Education, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, University of Oslo, Oslo, Norway., Storheim K; Division of Clinical Neuroscience, Department of Research, Innovation and Education, Oslo University Hospital, Oslo, Norway.; Department of Physiotherapy, Oslo Metropolitan University, Oslo, Norway., Pedersen LM; Division of Clinical Neuroscience, Department of Research, Innovation and Education, Oslo University Hospital, Oslo, Norway.; Department of Physiotherapy, Oslo Metropolitan University, Oslo, Norway., Lie BA; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Jan 07; Vol. 12 (1), pp. 215. Date of Electronic Publication: 2022 Jan 07.
DOI: 10.1038/s41598-021-04189-5
Abstrakt: Disability and distress caused by chronic low back pain (LBP) lacking clear pathoanatomical explanations cause huge problems both for patients and society. A subgroup of patients has Modic changes (MC), identifiable by MRI as vertebral bone marrow lesions. The cause of such changes and their relationship to pain are not yet understood. We explored the pathobiology of these lesions using profiling of gene expression in blood, coupled with an edema-sensitive MRI technique known as short tau inversion recovery (STIR) imaging. STIR images and total RNA from blood were collected from 96 patients with chronic LBP and MC type I, the most inflammatory MC state. We found the expression of 37 genes significantly associated with STIR signal volume, ten genes with edema abundancy (a constructed combination of STIR signal volume, height, and intensity), and one gene with expression levels significantly associated with maximum STIR signal intensity. Gene sets related to interferon signaling, mitochondrial metabolism and defense response to virus were identified as significantly enriched among the upregulated genes in all three analyses. Our results point to inflammation and immunological defense as important players in MC biology in patients with chronic LBP.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje