Lack of secondary hyperparathyroidism in sub-group of vitamin D deficient postmenopausal women: Is VDR gene polymorphism behind this mystery?

Autor: Dixit V; Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India. Electronic address: vivek_sgpgi@yahoo.com., Tripathi RL; Department of Biochemistry, UCMS & GTB Hospitals, Delhi, India., Dhanwal DK; Sr. Consultant Endocrinologist, NMC Super-speciality Hospitals, Abu Dhabi, United Arab Emirates.
Jazyk: angličtina
Zdroj: Diabetes & metabolic syndrome [Diabetes Metab Syndr] 2022 Jan; Vol. 16 (1), pp. 102381. Date of Electronic Publication: 2021 Dec 28.
DOI: 10.1016/j.dsx.2021.102381
Abstrakt: Background and Aims: We aimed to determine the cause of non-secondary hyperparathyroidism (Non-SHPT) in Indian postmenopausal women.
Materials & Methods: 334 apparently healthy postmenopausal women were assessed for bone mineral homeostaisis including Vitamin D, PTH and VDR polymorphism.
Results: 83% of the subjects had vitamin D deficiency further associated with VDR gene polymorphism (P 0.000). A sizable number of subjects (N = 83) did evoke SHPT despite low vitamin D levels. We observe that VDR gene polymorphism was strongly associated in the sub-group of non-SHPT.
Conclusion: lack of SHPT warrants researchers to study the pathophysiology of non-SHPT in detail to substantiate our findings.
(Copyright © 2021. Published by Elsevier Ltd.)
Databáze: MEDLINE
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