Structural disconnection of the posterior medial frontal cortex reduces speech error monitoring.

Autor:	McCall JD; Center for Brain Plasticity and Recovery and Neurology Department, Georgetown University Medical Center, Washington, DC 20007, USA., Vivian Dickens J; Center for Brain Plasticity and Recovery and Neurology Department, Georgetown University Medical Center, Washington, DC 20007, USA., Mandal AS; Center for Brain Plasticity and Recovery and Neurology Department, Georgetown University Medical Center, Washington, DC 20007, USA; Psychiatry Department, University of Cambridge, Cambridge CB2 1TN, UK., DeMarco AT; Center for Brain Plasticity and Recovery and Neurology Department, Georgetown University Medical Center, Washington, DC 20007, USA; Rehabilitation Medicine Department, Georgetown University Medical Center, Washington, DC 20007, USA., Fama ME; Center for Brain Plasticity and Recovery and Neurology Department, Georgetown University Medical Center, Washington, DC 20007, USA; Department of Speech, Language, and Hearing Sciences, The George Washington University, DC 20052, USA., Lacey EH; Center for Brain Plasticity and Recovery and Neurology Department, Georgetown University Medical Center, Washington, DC 20007, USA; Research Division, MedStar National Rehabilitation Hospital, Washington, DC 20010, USA., Kelkar A; Psychology Department, Drexel University, Philadelphia, PA 19104, USA., Medaglia JD; Psychology Department, Drexel University, Philadelphia, PA 19104, USA; Neurology Department, University of Pennsylvania, Philadelphia, PA 19104, USA., Turkeltaub PE; Center for Brain Plasticity and Recovery and Neurology Department, Georgetown University Medical Center, Washington, DC 20007, USA; Research Division, MedStar National Rehabilitation Hospital, Washington, DC 20010, USA; Rehabilitation Medicine Department, Georgetown University Medical Center, Washington, DC 20007, USA. Electronic address: turkeltp@georgetown.edu.
Jazyk:	angličtina
Zdroj:	NeuroImage. Clinical [Neuroimage Clin] 2022; Vol. 33, pp. 102934. Date of Electronic Publication: 2022 Jan 03.
DOI:	10.1016/j.nicl.2021.102934
Abstrakt:	Optimal performance in any task relies on the ability to detect and correct errors. The anterior cingulate cortex and the broader posterior medial frontal cortex (pMFC) are active during error processing. However, it is unclear whether damage to the pMFC impairs error monitoring. We hypothesized that successful error monitoring critically relies on connections between the pMFC and broader cortical networks involved in executive functions and the task being monitored. We tested this hypothesis in the context of speech error monitoring in people with post-stroke aphasia. Diffusion weighted images were collected in 51 adults with chronic left-hemisphere stroke and 37 age-matched control participants. Whole-brain connectomes were derived using constrained spherical deconvolution and anatomically-constrained probabilistic tractography. Support vector regressions identified white matter connections in which lost integrity in stroke survivors related to reduced error detection during confrontation naming. Lesioned connections to the bilateral pMFC were related to reduce error monitoring, including many connections to regions associated with speech production and executive function. We conclude that connections to the pMFC support error monitoring. Error monitoring in speech production is supported by the structural connectivity between the pMFC and regions involved in speech production, comprehension, and executive function. Interactions between pMFC and other task-relevant processors may similarly be critical for error monitoring in other task contexts. (Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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