Radiopaque fibrin nanocomplex as a promising tool for X-ray imaging applications.

Autor: Vedakumari SW; Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Chennai- 603 103, Tamil Nadu, India; Bio-products Laboratory, CSIR-Central Leather Research Institute, Adyar, Chennai 600 020, Tamil Nadu, India. Electronic address: drweslenv@gmail.com., Prabu P; Centre of Excellence for Advanced Materials Application, Slovak Academy of Sciences, Dúbravská cesta 9, Bratislava 84511, Slovakia., Jancy SJV; Electronics and Communication Engineering, SRM Institute of Science and Technology, Ramapuram Campus, Chennai 600 089, India., Pravin YR; Department of Physics (Science and Humanities), Agni College of Technology, OMR, Navallur, Thalambur, Chennai - 600 130, Tamil Nadu, India., Manickavasagam K; Department of General, Gastrointestinal and Minimal Access Surgery, St. Isabel's Hospital, Chennai 600004, Tamil Nadu, India., Sastry TP; CSIR-Central Leather Research Institute, Adyar, Chennai 600 020, Tamil Nadu, India. Electronic address: sastrytp@hotmail.com.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2022 Mar 01; Vol. 200, pp. 285-292. Date of Electronic Publication: 2022 Jan 04.
DOI: 10.1016/j.ijbiomac.2021.12.164
Abstrakt: The raising burden of cancer can be controlled by fabricating smart nanomaterials that can detect tumours easily. In this study, we report about the preparation of radiopaque fibrin nanocomplex (RFN) for imaging solid tumours. The nanocomplex exhibits high X-ray absorption and therefore utilizes X-ray radiography and computed tomography (CT) for imaging tumours. The CT images taken after intratumoral administration of RFN in tumor bearing mice displayed excellent visibility of tumour. Moreover, increased amount of RFN was seen at the site of tumour after 45 min of post-injection. These research findings prove the promising use of RFN as a valuable tool for imaging solid tumours.
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Databáze: MEDLINE
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