The Human-Milk Oligosaccharide Profile of Lactating Women in Dhaka, Bangladesh.

Autor:	Pell LG; Centre for Global Child Health and Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada., Ohuma EO; Centre for Global Child Health and Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada., Yonemitsu C; Department of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Centre of Research Excellence, University of California San Diego, La Jolla, CA, USA., Loutet MG; Centre for Global Child Health and Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada., Ahmed T; Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh., Mahmud AA; Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh., Azad MB; Manitoba Interdisciplinary Lactation Centre, Children's Hospital Research Institute of Manitoba, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada., Bode L; Department of Pediatrics and Larsson-Rosenquist Foundation Mother-Milk-Infant Centre of Research Excellence, University of California San Diego, La Jolla, CA, USA., Roth DE; Centre for Global Child Health and Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada.
Jazyk:	angličtina
Zdroj:	Current developments in nutrition [Curr Dev Nutr] 2021 Nov 13; Vol. 5 (12), pp. nzab137. Date of Electronic Publication: 2021 Nov 13 (Print Publication: 2021).
DOI:	10.1093/cdn/nzab137
Abstrakt:	Background: Human-milk oligosaccharides (HMOs) are an abundant component of human milk that have health-related effects on breastfeeding infants. Since variation in HMO composition can be explained by maternal and environmental factors, understanding the diversity in HMOs across settings and identifying context-specific factors associated with HMO abundances is important. Objectives: The aim was to describe the HMO profile of Bangladeshi women and to estimate the effect of maternal vitamin D supplementation on HMO composition. Methods: In a cross-sectional analysis of data and samples from the Maternal Vitamin D for Infant Growth trial in Dhaka, Bangladesh (clinicaltrials.gov; NCT01924013), 192 participants were randomly selected including 96 from each of the placebo and highest-dose vitamin D supplementation groups. In mid-feed breast milk samples collected at a mean (±SD) postpartum age of 93 ± 7 d, absolute and relative abundances of 19 HMOs were analyzed by HPLC. "Secretors" were defined as participants with 2'fucosyllactose concentrations >350 nmol/mL. Associations between HMO concentrations and selected maternal or environmental factors were estimated by multivariable linear regression, adjusting for vitamin D group allocation and secretor status. HMO profiles of Bangladeshi women were compared with data from other international cohorts. Results: Overall, 34% (65/192) of participants were nonsecretors. Secretor status was associated with the concentrations of total HMOs and 79% (15/19) of individual HMOs. Vitamin D supplementation did not affect the total or individual concentration of any measured HMO. 3-Fucosyllactose concentration was significantly higher in breast milk samples collected in December to February compared with samples collected in March to May. HMO composition was similar to other previously reported cohorts. Conclusions: The HMO profile of Bangladeshi women is predominantly determined by secretor status. Context-specific HMO data may improve understanding of the effects of HMOs on the infant microbiome and health and guide the development of HMO-containing interventions. (© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition.)
Databáze:	MEDLINE
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