Temporal pole blurring in temporal lobe epilepsy revealed by 3D Edge-Enhancing Gradient Echo MRI.

Autor:	Okromelidze L; Department of Radiology, Mayo Clinic, Jacksonville, FL, USA., Gupta V; Department of Radiology, Mayo Clinic, Jacksonville, FL, USA., Jain A; Department of Radiology, Mayo Clinic, Jacksonville, FL, USA., Gopal N; Department of Radiology, Mayo Clinic, Jacksonville, FL, USA., Feyissa AM; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Tatum WO 4th; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA., Quiñones-Hinojosa A; Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA., Grewal SS; Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA., Middlebrooks EH; Department of Radiology, Mayo Clinic, Jacksonville, FL, USA.; Department of Neurosurgery, Mayo Clinic, Jacksonville, FL, USA.
Jazyk:	angličtina
Zdroj:	The neuroradiology journal [Neuroradiol J] 2024 Jun; Vol. 37 (3), pp. 386-389. Date of Electronic Publication: 2022 Jan 06.
DOI:	10.1177/19714009211067404
Abstrakt:	While abnormalities of the hippocampus have been well characterized in temporal lobe epilepsy, various additional temporal lobe abnormalities have also been described. One poorly understood entity, the so-called temporal pole blurring (TPB), is one of the more frequently described neocortical abnormalities in TLE and is thought to represent dysmyelination and axonal loss due to chronic electrical perturbations in early age-onset temporal lobe epilepsy. In this study, we describe the first reported cases of TPB diagnosed by a recently described MRI sequence known as 3D Edge-Enhancing Gradient Echo (3D-EDGE), which has an effective "myelin weighting" making it exquisitely sensitive to this temporal pole dysmyelination. The value of detection of TPB lies in lateralizing seizure onset, as well as predicting a lower baseline neuropsychological performance compared to temporal lobe epilepsy without TPB. Additionally, it is critical to not mistake TPB for alternative diagnoses, such as focal cortical dysplasia or neoplasm. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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