Behavioral, Oxidative, and Biochemical Effects of Omega-3 on an Ovariectomized Rat Model of Menopause.
| Autor: | Da Rocha RVO; Graduate Program in Cellular and Molecular Biology, Lutheran University of Brazil (ULBRA), Canoas, Brazil., Martins MIM; Graduate Program in Cellular and Molecular Biology, Lutheran University of Brazil (ULBRA), Canoas, Brazil., Antunes FTT; Graduate Program in Cellular and Molecular Biology, Lutheran University of Brazil (ULBRA), Canoas, Brazil., Martins MG; Graduate Program in Genetic and Applied Toxicology, Lutheran University of Brazil (ULBRA), Canoas, Brazil., Klein AB; Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil., Corrêa DS; Graduate Program in Cellular and Molecular Biology, Lutheran University of Brazil (ULBRA), Canoas, Brazil., de Souza AH; Graduate Program in Cellular and Molecular Biology, Lutheran University of Brazil (ULBRA), Canoas, Brazil. alessandrahubnersouza@gmail.com. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of menopausal medicine [J Menopausal Med] 2021 Dec; Vol. 27 (3), pp. 132-140. |
| DOI: | 10.6118/jmm.21016 |
| Abstrakt: | Objectives: Menopause induces changes in neuronal transmission, leading to anxiety and depression. Changes in the brain's glutamate levels cause psychological behavior in postmenopausal women. Omega-3 has been studied to improve some of these behaviors. Methods: Twenty-four female Wistar rats were divided into four groups: sham-operated treated with water (SO-W), sham-operated treated with omega-3 (SO-O), ovariectomized (OVX) treated with water (OVX-W), and bilateral OVX treated with omega-3 (OVX-O). These treatments were performed for 20 days via gavage, before and after surgery, totaling 40 days. Results: In the forced swimming, elevated plus-maze, and open field tests to assess behaviors, such as depression and anxiety, omega-3 improved these behaviors in both treated groups. The levels of thiobarbituric acid reactive substances (TBARS) in the brain were not different between the groups; however, there was a significant decrease in the catalase activity in the SO-O group compared with the SO-W group ( P < 0.05). The glutamate level in the cerebrospinal fluid (CSF) was elevated in the SO-O group ( P < 0.001) but not in the OVX-W or OVX-O groups. Conclusions: These results bring novel data when related to the glutamatergic system in the SO-O group. This has suggested that the action mechanism of omega-3 was not dependent on glutamate levels in the CSF of the OVX group, but it played a regulatory role in the sham-operated animals. To confirm this, more studies are needed to explore this field when relating to the estrogen and glutamate receptor changes in specific brain regions. Competing Interests: No potential conflict of interest relevant to this article was reported. (Copyright © 2021 by The Korean Society of Menopause.) |
| Databáze: | MEDLINE |
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