| Autor: |
Qu W; of Translational Medicine, Zhejiang University, Hangzhou 310029, China., Zhuang Y; of Translational Medicine, Zhejiang University, Hangzhou 310029, China., Li X; of Translational Medicine, Zhejiang University, Hangzhou 310029, China. |
| Jazyk: |
angličtina |
| Zdroj: |
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences [Zhejiang Da Xue Xue Bao Yi Xue Ban] 2021 Oct 25; Vol. 50 (5), pp. 642-650. |
| DOI: |
10.3724/zdxbyxb-2021-0160 |
| Abstrakt: |
In neuronal system, epigenetic modifications are essential for neuronal development, the fate determination of neural stem cells and neuronal function. The dysfunction of epigenetic regulation is closely related to occurrence and development of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease. Abnormally elevated DNA methylation inhibits the expression of some DNA repair-related genes and affects the progression of Huntington's disease. In the brain of Alzheimer's disease patients, the levels of H3K27ac and H3K9ac histone modifications increased. In addition, the alteration of RNA methylation in animal models of Alzheimer's disease and Parkinson's disease showed discrepancy trends. Therefore, epigenetic modifications may serve as potential therapeutic targets for neurodegenerative diseases. Here, we summarize the recent progress of the roles of epigenetic modifications in neurodegenerative diseases. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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