Nosocomial Transmission of SARS-CoV-2 Involving Vaccinated Health Care Workers.

Autor:	Pérez-Lago L; Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Machado M; Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Gómez-Ruiz MM; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; Servicio de Prevención de Riesgos laborales, Gregorio Marañón General University Hospital, Madrid, Spain., Sola-Campoy PJ; Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Buenestado-Serrano S; Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., de la Cueva-García VM; Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Herranz M; Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain., Andrés Zayas C; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; Genomics Unit, Gregorio Marañón General University Hospital, Madrid, Spain., Sánchez-Arcilla I; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; Servicio de Prevención de Riesgos laborales, Gregorio Marañón General University Hospital, Madrid, Spain., Flores-García RF; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; Gerencia, Gregorio Marañón General University Hospital, Madrid, Spain., López-Fresneña N; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; Servicio de Medicina Preventiva y Gestión de Calidad, Gregorio Marañón General University Hospital, Madrid, Spain., García de San José S; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; Gerencia, Gregorio Marañón General University Hospital, Madrid, Spain., Catalán P; Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain., Muñoz P; Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain.; Departamento de Medicina, Universidad Complutense, Madrid, Spain., García de Viedma D; Servicio de Microbiología Clínica y Enfermedades Infecciosas, Gregorio Marañón General University Hospital, Madrid, Spain.; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.; CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain.
Jazyk:	angličtina
Zdroj:	Microbiology spectrum [Microbiol Spectr] 2022 Feb 23; Vol. 10 (1), pp. e0153221. Date of Electronic Publication: 2022 Jan 05.
DOI:	10.1128/spectrum.01532-21
Abstrakt:	COVID-19 vaccination has proven to be effective at preventing symptomatic disease but there are scarce data to fully understand whether vaccinated individuals can still behave as SARS-CoV-2 transmission vectors. Based on viral genome sequencing and detailed epidemiological interviews, we report a nosocomial transmission event involving two vaccinated health care-workers (HCWs) and four patients, one of them with fatal outcome. Strict transmission control measures, as during the prevaccination period, must be kept between HCWs and HCWs-patients in nosocomial settings. IMPORTANCE COVID-19 vaccination has proven to be effective at preventing symptomatic disease. Although some transmission events involving vaccinated cases have also been reported, scarce information is still available to fully understand whether vaccinated individuals may still behave as vectors in SARS-CoV-2 transmission events. Here, we report a SARS-CoV-2 nosocomial transmission event, supported on whole genome sequencing, in early March 2021 involving two vaccinated HCWs and four patients in our institution. Strict transmission control measures between HCWs and HCWs - patients in nosocomial settings must not be relaxed, and should be kept as strictly as during the prevaccination period.
Databáze:	MEDLINE
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