Respiratory alkalosis provokes spike-wave discharges in seizure-prone rats.

Autor:	Salvati KA; Department of Pharmacology, University of Virginia, Charlottesville, United States.; Neuroscience Graduate Program, University of Virginia, Charlottesville, United States., Souza GMPR; Department of Pharmacology, University of Virginia, Charlottesville, United States., Lu AC; Department of Pharmacology, University of Virginia, Charlottesville, United States.; Neuroscience Graduate Program, University of Virginia, Charlottesville, United States., Ritger ML; Department of Pharmacology, University of Virginia, Charlottesville, United States.; Neuroscience Graduate Program, University of Virginia, Charlottesville, United States., Guyenet P; Department of Pharmacology, University of Virginia, Charlottesville, United States., Abbott SB; Department of Pharmacology, University of Virginia, Charlottesville, United States., Beenhakker MP; Department of Pharmacology, University of Virginia, Charlottesville, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2022 Jan 04; Vol. 11. Date of Electronic Publication: 2022 Jan 04.
DOI:	10.7554/eLife.72898
Abstrakt:	Hyperventilation reliably provokes seizures in patients diagnosed with absence epilepsy. Despite this predictable patient response, the mechanisms that enable hyperventilation to powerfully activate absence seizure-generating circuits remain entirely unknown. By utilizing gas exchange manipulations and optogenetics in the WAG/Rij rat, an established rodent model of absence epilepsy, we demonstrate that absence seizures are highly sensitive to arterial carbon dioxide, suggesting that seizure-generating circuits are sensitive to pH. Moreover, hyperventilation consistently activated neurons within the intralaminar nuclei of the thalamus, a structure implicated in seizure generation. We show that intralaminar thalamus also contains pH-sensitive neurons. Collectively, these observations suggest that hyperventilation activates pH-sensitive neurons of the intralaminar nuclei to provoke absence seizures. Competing Interests: KS, GS, AL, MR, PG, SA, MB No competing interests declared (© 2022, Salvati et al.)
Databáze:	MEDLINE
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