Static CT myocardial perfusion imaging: image quality, artifacts including distribution and diagnostic performance compared to 82 Rb PET.

Autor: Inácio JR; Department of Radiology, The Ottawa Hospital, University of Ottawa Research Institute, University of Ottawa, Ottawa, Canada.; Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal., Srinivasan SB; Medical School, Harry Perkins Institute of Medical Research, The University of Western Australia, Perth, Australia., Ruddy TD; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada., deKemp RA; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada., Rybicki F; Department of Radiology, University of Cincinnati, Cincinnati, OH, USA.; Imagia, Montreal, QC, Canada., Beanlands RS; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada., Chow BJW; Department of Radiology, The Ottawa Hospital, University of Ottawa Research Institute, University of Ottawa, Ottawa, Canada.; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada., Dwivedi G; Medical School, Harry Perkins Institute of Medical Research, The University of Western Australia, Perth, Australia. girish.dwivedi@perkins.uwa.edu.au.; Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Canada. girish.dwivedi@perkins.uwa.edu.au.; Department of Advanced Clinical and Translational Cardiovascular Imaging, Harry Perkins Institute of Medical Research and Fiona Stanley Hospital, Murdoch, Australia. girish.dwivedi@perkins.uwa.edu.au.
Jazyk: angličtina
Zdroj: European journal of hybrid imaging [Eur J Hybrid Imaging] 2022 Jan 04; Vol. 6 (1), pp. 1. Date of Electronic Publication: 2022 Jan 04.
DOI: 10.1186/s41824-021-00118-x
Abstrakt: Background: Rubidium-82 positron emission tomography ( 82 Rb PET) MPI is considered a noninvasive reference standard for the assessment of myocardial perfusion in coronary artery disease (CAD) patients. Our main goal was to compare the diagnostic performance of static rest/ vasodilator stress CT myocardial perfusion imaging (CT-MPI) to stress/ rest 82 Rb PET-MPI for the identification of myocardial ischemia.
Methods: Forty-four patients with suspected or diagnosed CAD underwent both static CT-MPI and 82 Rb PET-MPI at rest and during pharmacological stress. The extent and severity of perfusion defects on PET-MPI were assessed to obtain summed stress score, summed rest score, and summed difference score. The extent and severity of perfusion defects on CT-MPI was visually assessed using the same grading scale. CT-MPI was compared with PET-MPI as the gold standard on a per-territory and a per-patient basis.
Results: On a per-patient basis, there was moderate agreement between CT-MPI and PET-MPI with a weighted 0.49 for detection of stress induced perfusion abnormalities. Using PET-MPI as a reference, static CT-MPI had 89% sensitivity (SS), 58% specificity (SP), 71% accuracy (AC), 88% negative predictive value (NPV), and 59% positive predictive value (PPV) to diagnose stress-rest perfusion deficits on a per-patient basis. On a per-territory analysis, CT-MPI had 73% SS, 65% SP, 67% AC, 90.8% NPV, and 34% PPV to diagnose perfusion deficits.
Conclusions: CT-MPI has high sensitivity and good overall accuracy for the diagnosis of functionally significant CAD using 82 Rb PET-MPI as the reference standard. CT-MPI may play an important role in assessing the functional significance of CAD especially in combination with CCTA.
(© 2022. The Author(s).)
Databáze: MEDLINE
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