Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.

Autor: Dejnirattisai W; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Huo J; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK., Zhou D; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Zahradník J; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Supasa P; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Liu C; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK., Duyvesteyn HME; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK., Ginn HM; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK., Mentzer AJ; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Tuekprakhon A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Nutalai R; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Wang B; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Dijokaite A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Khan S; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Avinoam O; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Bahar M; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK., Skelly D; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Peter Medawar Building for Pathogen Research, Oxford, UK.; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Adele S; Peter Medawar Building for Pathogen Research, Oxford, UK., Johnson SA; Peter Medawar Building for Pathogen Research, Oxford, UK., Amini A; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Translational Gastroenterology Unit, University of Oxford, Oxford, UK.; Peter Medawar Building for Pathogen Research, Oxford, UK., Ritter T; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Mason C; Oxford University Hospitals NHS Foundation Trust, Oxford, UK., Dold C; NIHR Oxford Biomedical Research Centre, Oxford, UK.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Pan D; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust.; Department of Respiratory Sciences, University of Leicester., Assadi S; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust., Bellass A; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust., Omo-Dare N; Department of Infectious Diseases and HIV Medicine, University Hospitals of Leicester NHS Trust., Koeckerling D; Medical Sciences Division, University of Oxford., Flaxman A; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Jenkin D; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Aley PK; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Voysey M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Clemens SAC; Institute of Global Health, University of Siena, Siena, Brazil; Department of Paediatrics, University of Oxford, Oxford, UK., Naveca FG; Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Amazonas, Brazil., Nascimento V; Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Amazonas, Brazil., Nascimento F; Laboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Amazonas, Brazil., Fernandes da Costa C; Fundação de Vigilância em Saúde do Amazonas, Manaus, Amazonas, Brazil., Resende PC; Laboratorio de vírus respiratórios- IOC/FIOCRUZ, Rio de Janeiro, Brazil., Pauvolid-Correa A; Laboratorio de vírus respiratórios- IOC/FIOCRUZ, Rio de Janeiro, Brazil.; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, United States., Siqueira MM; Laboratorio de vírus respiratórios- IOC/FIOCRUZ, Rio de Janeiro, Brazil., Baillie V; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Serafin N; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Ditse Z; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Da Silva K; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Madhi S; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Nunes MC; South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Science and Technology/National Research Foundation, South African Research Chair Initiative in Vaccine Preventable Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Malik T; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK., Openshaw PJ; National Heart & Lung Institute, Imperial College London., Baillie JK; Genetics and Genomics, Roslin Institute, University of Edinburgh, Edinburgh, UK., Semple MG; NIHR Health Protection Research Unit, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK., Townsend AR; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK., Huang KA; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan., Tan TK; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, UK., Carroll MW; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK., Klenerman P; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Peter Medawar Building for Pathogen Research, Oxford, UK.; Translational Gastroenterology Unit, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK., Barnes E; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Peter Medawar Building for Pathogen Research, Oxford, UK.; Translational Gastroenterology Unit, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK., Dunachie SJ; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Peter Medawar Building for Pathogen Research, Oxford, UK.; Centre For Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand, Department of Medicine, University of Oxford, Oxford, UK., Constantinides B; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Webster H; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Crook D; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Pollard AJ; NIHR Oxford Biomedical Research Centre, Oxford, UK.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Lambe T; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK., Paterson NG; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK., Williams MA; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK., Hall DR; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK., Fry EE; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK., Mongkolsapaya J; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.; Siriraj Center of Research Excellence in Dengue & Emerging Pathogens, Dean Office for Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand., Ren J; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK., Schreiber G; Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel., Stuart DI; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.; Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford, UK., Screaton GR; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Jazyk: angličtina
Zdroj: BioRxiv : the preprint server for biology [bioRxiv] 2021 Dec 22. Date of Electronic Publication: 2021 Dec 22.
DOI: 10.1101/2021.12.03.471045
Abstrakt: On the 24 th November 2021 the sequence of a new SARS CoV-2 viral isolate spreading rapidly in Southern Africa was announced, containing far more mutations in Spike (S) than previously reported variants. Neutralization titres of Omicron by sera from vaccinees and convalescent subjects infected with early pandemic as well as Alpha, Beta, Gamma, Delta are substantially reduced or fail to neutralize. Titres against Omicron are boosted by third vaccine doses and are high in cases both vaccinated and infected by Delta. Mutations in Omicron knock out or substantially reduce neutralization by most of a large panel of potent monoclonal antibodies and antibodies under commercial development. Omicron S has structural changes from earlier viruses, combining mutations conferring tight binding to ACE2 to unleash evolution driven by immune escape, leading to a large number of mutations in the ACE2 binding site which rebalance receptor affinity to that of early pandemic viruses.
Databáze: MEDLINE