Mechanically evoked defensive attack is controlled by GABAergic neurons in the anterior hypothalamic nucleus.

Autor: Xie Z; National Institute of Biological Sciences, Beijing, China., Gu H; National Institute of Biological Sciences, Beijing, China.; College of Life Sciences, Beijing Normal University, Beijing, China., Huang M; Bioland Laboratories, Guangzhou, China., Cheng X; National Institute of Biological Sciences, Beijing, China.; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China., Shang C; Bioland Laboratories, Guangzhou, China., Tao T; National Institute of Biological Sciences, Beijing, China., Li D; Department of Neurobiology, School of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China., Xie Y; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, China., Zhao J; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China., Lu W; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China., Zhang Z; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China., Zhan C; National Institute of Biological Sciences, Beijing, China.; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China., Tang Z; School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, China., Zhang F; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, China. zhangfan86@hebmu.edu.cn., Cao P; National Institute of Biological Sciences, Beijing, China. caopeng@nibs.ac.cn.; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China. caopeng@nibs.ac.cn.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2022 Jan; Vol. 25 (1), pp. 72-85. Date of Electronic Publication: 2022 Jan 03.
DOI: 10.1038/s41593-021-00985-4
Abstrakt: Innate defensive behaviors triggered by environmental threats are important for animal survival. Among these behaviors, defensive attack toward threatening stimuli (for example, predators) is often the last line of defense. How the brain regulates defensive attack remains poorly understood. Here we show that noxious mechanical force in an inescapable context is a key stimulus for triggering defensive attack in laboratory mice. Mechanically evoked defensive attacks were abrogated by photoinhibition of vGAT + neurons in the anterior hypothalamic nucleus (AHN). The vGAT + AHN neurons encoded the intensity of mechanical force and were innervated by brain areas relevant to pain and attack. Activation of these neurons triggered biting attacks toward a predator while suppressing ongoing behaviors. The projection from vGAT + AHN neurons to the periaqueductal gray might be one AHN pathway participating in mechanically evoked defensive attack. Together, these data reveal that vGAT + AHN neurons encode noxious mechanical stimuli and regulate defensive attack in mice.
(© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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