Effect of Calcium and Vitamin D Supplementation With and Without Collagen Peptides on Volumetric and Areal Bone Mineral Density, Bone Geometry and Bone Turnover in Postmenopausal Women With Osteopenia.

Autor:	Lampropoulou-Adamidou K; Laboratory for Research of the Musculoskeletal System 'Th. Garofalidis', Medical School, National and Kapodistrian University of Athens, KAT General Hospital of Athens, Athens, Greece. Electronic address: kilampropoulou@gmail.com., Karlafti E; Laboratory for Research of the Musculoskeletal System 'Th. Garofalidis', Medical School, National and Kapodistrian University of Athens, KAT General Hospital of Athens, Athens, Greece., Argyrou C; Laboratory for Research of the Musculoskeletal System 'Th. Garofalidis', Medical School, National and Kapodistrian University of Athens, KAT General Hospital of Athens, Athens, Greece., Makris K; Clinical Biochemistry Department, KAT General Hospital of Athens, Athens, Greece., Trovas G; Laboratory for Research of the Musculoskeletal System 'Th. Garofalidis', Medical School, National and Kapodistrian University of Athens, KAT General Hospital of Athens, Athens, Greece., Dontas IA; Laboratory for Research of the Musculoskeletal System 'Th. Garofalidis', Medical School, National and Kapodistrian University of Athens, KAT General Hospital of Athens, Athens, Greece., Tournis S; Laboratory for Research of the Musculoskeletal System 'Th. Garofalidis', Medical School, National and Kapodistrian University of Athens, KAT General Hospital of Athens, Athens, Greece., Triantafyllopoulos IK; Laboratory for Research of the Musculoskeletal System 'Th. Garofalidis', Medical School, National and Kapodistrian University of Athens, KAT General Hospital of Athens, Athens, Greece; 5th Orthopaedic Department, HYGEIA Hospital, Athens, Greece.
Jazyk:	angličtina
Zdroj:	Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry [J Clin Densitom] 2022 Jul-Sep; Vol. 25 (3), pp. 357-372. Date of Electronic Publication: 2021 Nov 25.
DOI:	10.1016/j.jocd.2021.11.011
Abstrakt:	Collagen peptides (CPs) have been shown to potentially have a role as a treatment option in osteopenia. In the present randomized prospective study, we examined the effect of calcium, vitamin D with and without CPs supplementation on changes in volumetric bone mineral density (vBMD) and bone geometry assessed by peripheral quantitative computed tomography at the tibia, areal bone mineral density (aBMD) assessed by dual-energy X-ray absorptiometry at the lumbar spine and the hip and bone turnover markers over 12-mo. Fifty-one postmenopausal women with osteopenia were allocated to Group A who received orally 5 g CPs, 500 mg calcium and 400 IU vitamin D3 and Group B who received the same dose of calcium and vitamin D3 per day. The primary endpoint was the change of trabecular bone mineral content (BMC) and vBMD after 12-mo supplementation in Groups A and B. At the trabecular site (4% of the tibia length), Group A had a significant increase of total BMC by 1.96 ± 2.41% and cross-sectional area by 2.58 ± 3.91%, trabecular BMC by 5.24 ± 6.48%, cross-sectional area by 2.58 ± 3.91% and vBMD by 2.54 ± 3.43% and a higher % change of these parameters at 12 mo in comparison to Group B (p < 0.01, p = 0.04, p < 0.01, p = 0.04, p = 0.02, respectively). At the cortical site (38% of the tibia length), total and cortical vBMD increased by 1.01 ± 2.57% and 0.67 ± 1.71%. Furthermore, the mean aBMD at the spine was higher (p = 0.01), while bone markers decreased in Group A compared to Group B. The present study shows improvement of trabecular and cortical parameters as assessed by peripheral quantitative computed tomography at the tibia, prevention of aBMD decline and decrease of bone turnover after 12-mo supplementation with calcium, vitamin D with CPs. (Copyright © 2021 The International Society for Clinical Densitometry. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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