Metabolic Syndrome and Risk of Breast Cancer by Molecular Subtype: Analysis of the MEND Study.

Autor: Akinyemiju T; Department of Population Health Sciences, School of Medicine, Duke University, Durham, NC; Duke Cancer Institute, School of Medicine, Duke University, Durham, NC; Duke Global Health Institute, Duke University, Durham, NC. Electronic address: tomi.akinyemiju@duke.edu., Oyekunle T; Department of Population Health Sciences, School of Medicine, Duke University, Durham, NC., Salako O; College of Medicine and Lagos University Teaching Hospital, University of Lagos, Lagos, Nigeria., Gupta A; Department of Population Health Sciences, School of Medicine, Duke University, Durham, NC., Alatise O; Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria., Ogun G; Unversity College Hospital, University of Ibadan, Ibadan, Oyo State, Nigeria., Adeniyi A; Federal Medical Center, Abeokuta, Ogun State, Nigeria., Deveaux A; Department of Population Health Sciences, School of Medicine, Duke University, Durham, NC., Hall A; Department of Pathology, School of Medicine, Duke University, Durham, NC., Ayandipo O; Unversity College Hospital, University of Ibadan, Ibadan, Oyo State, Nigeria., Olajide T; College of Medicine and Lagos University Teaching Hospital, University of Lagos, Lagos, Nigeria., Olasehinde O; Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria., Arowolo O; Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria., Adisa A; Obafemi Awolowo University Teaching Hospital, Ile-Ife, Osun State, Nigeria., Afuwape O; Unversity College Hospital, University of Ibadan, Ibadan, Oyo State, Nigeria., Olusanya A; Unversity College Hospital, University of Ibadan, Ibadan, Oyo State, Nigeria., Adegoke A; Our Lady of Apostle Catholic Hospital, Ibadan, Oyo State, Nigeria., Tollefsbol TO; University of Alabama at Birmingham, Birmingham, AL., Arnett D; College of Public Health, University of Kentucky, Lexington, KY., Muehlbauer MJ; Duke Molecular Physiology Institute, School of Medicine, Duke University, Durham, NC., Newgard CB; Duke Molecular Physiology Institute, School of Medicine, Duke University, Durham, NC., Daramola A; College of Medicine and Lagos University Teaching Hospital, University of Lagos, Lagos, Nigeria; University of Kansas Medical Center, Kansas City, KS.
Jazyk: angličtina
Zdroj: Clinical breast cancer [Clin Breast Cancer] 2022 Jun; Vol. 22 (4), pp. e463-e472. Date of Electronic Publication: 2021 Nov 23.
DOI: 10.1016/j.clbc.2021.11.004
Abstrakt: Background: Metabolic syndrome (MetS) is characterized by a cluster of biological irregularities. The purpose of this analysis was to examine the association of MetS with BC among Nigerian women, and for the first time evaluate this association by molecular subtype.
Materials and Methods: MetS was defined as having at least 3 out of 5 of: high blood pressure (≥ 130/85 mm Hg), reduced HDL (< 50 mg/dL), elevated triglyceride (> 150 mg/dL), high waist circumference (≥ 80 cm), and prior diagnosis of diabetes or elevated fasting glucose level (≥ 100 mg/dL). Among 296 newly diagnosed BC cases and 259 healthy controls, multivariable logistic regression models were utilized to estimate adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) for the association between MetS and BC overall. Multinomial logistic regression models were used to evaluate each molecular subtype (Luminal A, Luminal B, HER2-enriched and triple-negative or TNBC).
Results: After adjusting for age, socio-demographic and reproductive risk factors, there was a positive association between MetS and BC (aOR: 1.84, 95% CI: 1.07, 3.16). In stratified analyses, MetS was associated with BC regardless of BMI status; however, the estimate was significant only among normal weight women (aOR: 3.85; 95% CI: 1.25, 11.90). MetS was significantly associated with TNBC subtype (aOR: 4.37, 95% CI: 1.67, 11.44); associations for other molecular subtypes were not statistically significant.
Conclusion: MetS appears to be a robust risk factor for BC, particularly for TNBC. Public health and clinical interventions can provide substantial benefits in reducing the burden of MetS and preventing BC among Nigerian women.
(Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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