Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma.

Autor:	Lechner M; UCL Cancer Institute, University College London, London, UK; Academic Head and Neck Centre, UCL Division of Surgery and Interventional Science, University College London, London, UK; ENT Department, Barts Health NHS Trust, London, United Kingdom; Rhinology & Endoscopic Skull Base Surgery, Department of Otolaryngology-H&N Surgery, Stanford University School of Medicine, Palo Alto, USA. Electronic address: m.lechner@ucl.ac.uk., Takahashi Y; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, USA., Turri-Zanoni M; Unit of Otorhinolaryngology and Head & Neck Surgery, Department of Biotechnology and Life Sciences, ASST Sette Laghi, University of Insubria, Varese, Italy., Liu J; UCL Cancer Institute, University College London, London, UK., Counsell N; Cancer Research UK & UCL Cancer Trials Centre, University College London, London, UK., Hermsen M; Department of Head and Neck Oncology, Instituto de Investigacio´n Sanitaria Del Principado de Asturias (ISPA), Instituto Universitario de Oncologı´a Del Principado de Asturias (IUOPA), Centro de Investigacio´n Biome´dica en Red (CIBER-ONC), Oviedo, Spain., Kaur RP; Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, USA., Zhao T; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA., Ramanathan M Jr; Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, USA., Schartinger VH; Department of Otorhinolaryngology, Medical University of Innsbruck, Innsbruck, Austria., Emanuel O; UCL Cancer Institute, University College London, London, UK., Helman S; Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, USA., Varghese J; Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, USA., Dudas J; Department of Otorhinolaryngology, Medical University of Innsbruck, Innsbruck, Austria., Riechelmann H; Department of Otorhinolaryngology, Medical University of Innsbruck, Innsbruck, Austria., Sprung S; Institute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria., Haybaeck J; Institute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria; Diagnostic & Research Center for Molecular BioMedicine, Institute of Pathology, Medical University Graz, Graz, Austria., Howard D; Head and Neck Cancer Unit, Imperial College Healthcare NHS Trust, London, UK., Engel NW; Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Stewart S; Head and Neck Centre, University College London Hospitals NHS Trust, London, UK., Brooks L; Head and Neck Centre, University College London Hospitals NHS Trust, London, UK., Pickles JC; Department of Developmental Biology and Cancer & Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Jacques TS; Department of Developmental Biology and Cancer & Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Fenton TR; School of Biosciences, University of Kent, Canterbury, UK; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Williams L; UCL Division of Surgery and Interventional Science, University College London, London, UK., Vaz FM; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK., O'Flynn P; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK., Stimpson P; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK., Wang S; Institute of Nuclear Medicine, University College London, London, UK., Hannan SA; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK., Unadkat S; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK., Hughes J; Head and Neck Centre, University College London Hospitals NHS Trust, London, UK., Dwivedi R; Head and Neck Centre, University College London Hospitals NHS Trust, London, UK., Forde CT; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK., Randhawa P; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK., Gane S; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK., Joseph J; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK., Andrews PJ; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK., Royle G; UCL Cancer Institute, University College London, London, UK., Franchi A; Department of Translational Research, University of Pisa, Pisa, Italy., Maragliano R; Department of Medicine and Surgery, Unit of Pathology, University of Insubria, Varese, Italy., Battocchio S; Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia, ASST Spedali Civili, Brescia, Italy., Bewicke-Copley H; UCL Cancer Institute, University College London, London, UK., Pipinikas C; UCL Cancer Institute, University College London, London, UK., Webster A; UCL Cancer Institute, University College London, London, UK., Thirlwell C; UCL Cancer Institute, University College London, London, UK; College of Medicine and Health and Institute of Biomedical and Clinical Science, University of Exeter, Exeter, UK., Ho D; Stem Cell Institute, University of Cambridge, Cambridge, UK., Teschendorff A; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Shanghai, China., Zhu T; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Shanghai, China., Steele CD; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA., Pillay N; UCL Cancer Institute, University College London, London, UK., Vanhaesebroeck B; UCL Cancer Institute, University College London, London, UK., Mohyeldin A; Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, USA., Fernandez-Miranda J; Department of Neurosurgery, Stanford University School of Medicine, Palo Alto, USA., Park KW; Rhinology & Endoscopic Skull Base Surgery, Department of Otolaryngology-H&N Surgery, Stanford University School of Medicine, Palo Alto, USA., Le QT; Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, USA., West RB; Department of Radiation Oncology, Stanford University School of Medicine, Palo Alto, USA., Saade R; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, USA., Manes RP; Department of Neurosurgery, Yale School of Medicine, New Haven, USA., Omay SB; Department of Neurosurgery, Yale School of Medicine, New Haven, USA., Vining EM; Department of Neurosurgery, Yale School of Medicine, New Haven, USA., Judson BL; Department of Neurosurgery, Yale School of Medicine, New Haven, USA., Yarbrough WG; Department of Otolaryngology/Head and Neck Surgery, UNC School of Medicine, Chapel Hill, NC, USA., Sansovini M; Therapeutic Nuclear Medicine, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Silvia N; Therapeutic Nuclear Medicine, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Grassi I; Therapeutic Nuclear Medicine, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Bongiovanni A; Osteoncology and Rare Tumors Center (CDO-TR), IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Capper D; Department of Neuropathology, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Berlin, Germany; German Cancer Consortium (DKTK), Partner Site Berlin, German Cancer Research Center (DKFZ), Heidelberg, Germany., Schüller U; Department of Pediatric Hematology and Oncology, Institute of Neuropathology, And Research Institute Children's Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Thavaraj S; Centre for Clinical, Oral & Translational Science, King's College London, Department of Head and Neck Pathology, Guy's Hospital, London, UK., Sandison A; Department of Head and Neck Pathology, Guy's Hospital, London, UK., Surda P; Guy's Hospital, King's College, London, UK., Hopkins C; Guy's Hospital, King's College, London, UK., Ferrari M; Section of Otorhinolaryngology - Head and Neck Surgery, Department of Neurosciences, University of Padova, Italy., Mattavelli D; Unit of Otorhinolaryngology - Head and Neck Surgery, Department of Medical and Surgical Specialities, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy., Rampinelli V; Unit of Otorhinolaryngology - Head and Neck Surgery, Department of Medical and Surgical Specialities, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy., Facchetti F; Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia, ASST Spedali Civili, Brescia, Italy., Nicolai P; Section of Otorhinolaryngology - Head and Neck Surgery, Department of Neurosciences, University of Padova, Italy., Bossi P; Medical Oncology, Department of Medical and Surgical Specialities, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy., Henriquez OA; Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, USA., Magliocca K; Department of Pathology, Emory University School of Medicine, Atlanta, USA., Solares CA; Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, USA., Wise SK; Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, USA., Llorente JL; Dept Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain., Patel ZM; Rhinology & Endoscopic Skull Base Surgery, Department of Otolaryngology-H&N Surgery, Stanford University School of Medicine, Palo Alto, USA., Nayak JV; Rhinology & Endoscopic Skull Base Surgery, Department of Otolaryngology-H&N Surgery, Stanford University School of Medicine, Palo Alto, USA., Hwang PH; Rhinology & Endoscopic Skull Base Surgery, Department of Otolaryngology-H&N Surgery, Stanford University School of Medicine, Palo Alto, USA., Lacy PD; Department of Otolaryngology, Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland., Woods R; Department of Otolaryngology, Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland., O'Neill JP; Department of Otolaryngology, Head and Neck Surgery, Beaumont Hospital, Dublin, Ireland; The Royal College of Surgeons in Ireland, Dublin, Ireland., Jay A; Department of Histopathology, University College London Hospitals NHS Trust, London, UK., Carnell D; Head and Neck Centre, University College London Hospitals NHS Trust, London, UK., Forster MD; UCL Cancer Institute, University College London, London, UK; Academic Head and Neck Centre, UCL Division of Surgery and Interventional Science, University College London, London, UK; Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Ishii M; Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, USA., London NR Jr; Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, USA; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA; Sinonasal and Skull Base Tumor Program, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA., Bell DM; Department of Pathology, The University of Texas MD Anderson Cancer Center Houston, USA; Division of Anatomic Pathology, City of Hope Comprehensive Cancer Center, Duarte, CA, United States., Gallia GL; Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, USA; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA., Castelnuovo P; Unit of Otorhinolaryngology and Head & Neck Surgery, Department of Biotechnology and Life Sciences, ASST Sette Laghi, University of Insubria, Varese, Italy., Severi S; Therapeutic Nuclear Medicine, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) 'Dino Amadori', Meldola, Italy., Lund VJ; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK. Electronic address: v.lund@ucl.ac.uk., Hanna EY; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address: EYHanna@mdanderson.org.
Jazyk:	angličtina
Zdroj:	European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2022 Feb; Vol. 162, pp. 221-236. Date of Electronic Publication: 2021 Dec 31.
DOI:	10.1016/j.ejca.2021.09.046
Abstrakt:	Introduction: Olfactory neuroblastoma (ONB) is a rare cancer of the sinonasal region. We provide a comprehensive analysis of this malignancy with molecular and clinical trial data on a subset of our cohort to report on the potential efficacy of somatostatin receptor 2 (SSTR2)-targeting imaging and therapy. Methods: We conducted a retrospective analysis of 404 primary, locally recurrent, and metastatic olfactory neuroblastoma (ONB) patients from 12 institutions in the United States of America, United Kingdom and Europe. Clinicopathological characteristics and treatment approach were evaluated. SSTR2 expression, SSTR2-targeted imaging and the efficacy of peptide receptor radionuclide therapy [PRRT]( 177 Lu-DOTATATE) were reported in a subset of our cohort (LUTHREE trial; NCT03454763). Results: Dural infiltration at presentation was a significant predictor of overall survival (OS) and disease-free survival (DFS) in primary cases (n = 278). Kadish-Morita staging and Dulguerov T-stage both had limitations regarding their prognostic value. Multivariable survival analysis demonstrated improved outcomes with lower stage and receipt of adjuvant radiotherapy. Prophylactic neck irradiation significantly reduces the rate of nodal recurrence. 82.4% of the cohort were positive for SSTR2; treatment of three metastatic cases with SSTR2-targeted peptide-radionuclide receptor therapy (PRRT) in the LUTHREE trial was well-tolerated and resulted in stable disease (SD). Conclusions: This study presents pertinent clinical data from the largest dataset, to date, on ONB. We identify key prognostic markers and integrate these into an updated staging system, highlight the importance of adjuvant radiotherapy across all disease stages, the utility of prophylactic neck irradiation and the potential efficacy of targeting SSTR2 to manage disease. Competing Interests: Conflict of interest statement NL receives research funding from Merck Inc., not related to this manuscript, and was a consultant for CoolTech Inc. and holds stock in Navigen Pharmaceuticals, both of which are unrelated to this manuscript. SW is on the advisory board of ALK, Genentech, OptiNose, SinopSys and a Consultant to NeurENT, Stryker, all of which are unrelated to this manuscript. All other authors declare no potential relevant conflicts of interest. (Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze:	MEDLINE
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