[Renal involvement in monoclonal gammopathies].

Autor:	Ibáñez Moreno JA; Departamento de Patología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia. Electronic address: jairo.ibanez@udea.edu.co., Bacca González JM; Departamento de Patología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia., Taborda Murillo A; Departamento de Patología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia., Ospina Ospina S; Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia., Arias LF; Departamento de Patología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Jazyk:	Spanish; Castilian
Zdroj:	Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia [Rev Esp Patol] 2022 Jan-Mar; Vol. 55 (1), pp. 4-11. Date of Electronic Publication: 2021 Aug 06.
DOI:	10.1016/j.patol.2021.06.002
Abstrakt:	Introduction: The kidney is one of the organs most frequently affected by disease processes which produce monoclonal immunoglobins, therefore renal morphological and immunopathological alterations should be clearly recognized. Objective: To describe the pathological features of renal involvement in monoclonal gammopathies. Material and Methods: A descriptive, retrospective and cross-sectional study of renal biopsies studied in a single center during a period of 14 years was carried out. Results: 102 cases were included, of which 53% were male patients and the median age was 62.5 years (range 34 - 79). 97% of the biopsies were from native kidneys. The most frequent histopathological diagnosis (31.4%) was myeloma kidney, with kappa being the light chain most frequently deposited (65.6% of cases). AL amyloidosis was the second most common (29.4%) where the lambda chain predominated in 86.6%, followed by light chain deposition disease (20.6%) with the predominance of the kappa chain in 66.6%. Conclusions: The most frequent renal involvement due to monoclonal gammopathies was myeloma kidney with deposition of kappa light chains, followed by AL lambda amyloidosis; these diseases were found more frequently in patients over 50 years of age. (Copyright © 2021 Sociedad Española de Anatomía Patológica. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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