Oscillometry and Asthma Control in Patients With and Without Fixed Airflow Obstruction.
| Autor: | Cottee AM; Department of Respiratory Medicine, Concord Repatriation General Hospital, Concord, NSW, Australia; Woolcock Emphysema Centre and Airway Physiology and Imaging Group, Woolcock Institute of Medical Research, Glebe, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. Electronic address: alice.cottee@sydney.edu.au., Seccombe LM; Department of Respiratory Medicine, Concord Repatriation General Hospital, Concord, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia., Thamrin C; Woolcock Emphysema Centre and Airway Physiology and Imaging Group, Woolcock Institute of Medical Research, Glebe, NSW, Australia., King GG; Woolcock Emphysema Centre and Airway Physiology and Imaging Group, Woolcock Institute of Medical Research, Glebe, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia; Department of Respiratory Medicine, Royal North Shore Hospital, St Leonards, NSW, Australia., Peters MJ; Department of Respiratory Medicine, Concord Repatriation General Hospital, Concord, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia; Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, NSW, Australia., Farah CS; Department of Respiratory Medicine, Concord Repatriation General Hospital, Concord, NSW, Australia; Woolcock Emphysema Centre and Airway Physiology and Imaging Group, Woolcock Institute of Medical Research, Glebe, NSW, Australia; Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia; Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, NSW, Australia. |
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| Jazyk: | angličtina |
| Zdroj: | The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2022 May; Vol. 10 (5), pp. 1260-1267.e1. Date of Electronic Publication: 2022 Jan 01. |
| DOI: | 10.1016/j.jaip.2021.12.026 |
| Abstrakt: | Background: Asthma is defined by the presence of reversible airflow limitation, yet persistently abnormal spirometry may develop despite appropriate asthma treatment. Fixed airflow obstruction (FAO) describes abnormal postbronchodilator spirometry that is associated with greater symptom burden and disease severity. Respiratory oscillometry measures the mechanics of the entire airway tree, including peripheral airway changes that have been shown to influence asthma symptoms. Objective: To evaluate the relationship between abnormal oscillometry following bronchodilator and symptom control in adults with asthma. Methods: A prospective cohort of patients with asthma attending an airways clinic completed oscillometry (resistance and reactance), spirometry, and the Asthma Control Test. Postbronchodilator lung function below the lower limit of normal was considered abnormal. Spirometric FAO was defined as FEV Results: Ninety patients with asthma were included; 48% had spirometric FAO. Only reactance parameters, not spirometry, significantly related to (r Conclusions: Reactance related to asthma control, independently of spirometric FAO. Abnormal postbronchodilator reactance identified more patients with poor asthma control compared with spirometry. These findings confirm that oscillometry is a relevant lung function test in the clinical assessment of asthma. (Copyright © 2022 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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