Environmental Enrichment Differentially Activates Neural Circuits in FVB/N Mice, Inducing Social Interaction in Females but Agonistic Behavior in Males.

Autor: Cabrera-Muñoz EA; Laboratorio of Neurogénesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría 'Ramón de La Fuente Muñiz', Calzada México-Xochimilco No. 101, Colonia San Lorenzo Huipulco, Delegación Tlalpan, C.P. 14370, México City, México., Olvera-Hernández S; Laboratorio of Neurogénesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría 'Ramón de La Fuente Muñiz', Calzada México-Xochimilco No. 101, Colonia San Lorenzo Huipulco, Delegación Tlalpan, C.P. 14370, México City, México., Vega-Rivera NM; Laboratorio of Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría 'Ramón de La Fuente Muñiz', Calzada México-Xochimilco 101, C.P. 14370, México City, México., Meneses-San Juan D; Laboratorio of Neurogénesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría 'Ramón de La Fuente Muñiz', Calzada México-Xochimilco No. 101, Colonia San Lorenzo Huipulco, Delegación Tlalpan, C.P. 14370, México City, México., Reyes-Haro D; Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología. Universidad Nacional Autónoma de México, Campus Juriquilla. Boulevard Juriquilla 3001, C.P. 76230, Juriquilla, Querétaro, México., Ortiz-López L; Laboratorio of Neurogénesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría 'Ramón de La Fuente Muñiz', Calzada México-Xochimilco No. 101, Colonia San Lorenzo Huipulco, Delegación Tlalpan, C.P. 14370, México City, México., Ramírez Rodríguez GB; Laboratorio of Neurogénesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría 'Ramón de La Fuente Muñiz', Calzada México-Xochimilco No. 101, Colonia San Lorenzo Huipulco, Delegación Tlalpan, C.P. 14370, México City, México. gbernabe@imp.edu.mx.
Jazyk: angličtina
Zdroj: Neurochemical research [Neurochem Res] 2022 Mar; Vol. 47 (3), pp. 781-794. Date of Electronic Publication: 2022 Jan 03.
DOI: 10.1007/s11064-021-03487-8
Abstrakt: Environmental enrichment induces behavioral and structural modifications in rodents and influences the capability of mice to cope with stress. However, little is understood about hippocampal neurogenesis and the appearance of social/agonistic (aggressive) behavior upon activation of different neuronal circuits in FVB/N mice. Thus, in this study we hypothesized that environmental enrichment differentially regulates neurogenesis, neural circuit activation and social/agonistic behavior in male and female FVB/N mice. We explored the (1) neurogenic process as an indicative of neuroplasticity, (2) neuronal activation in the limbic system, and (3) social behavior using the resident-intruder test. On postnatal day 23 (PD23), mice were assigned to one of two groups: Standard Housing or Environmental Enrichment. At PD53, rodents underwent the resident-intruder test to evaluate social behaviors. Results revealed that environmental enrichment increased neurogenesis and social interaction in females. In males, environmental enrichment increased neurogenesis and agonistic behavior. Enriched male mice expressed higher levels of agonistic-related behavior than female mice housed under the same conditions. Neural circuit analysis showed lower activation in the amygdala of enriched males and higher activation in enriched females than their respective controls. Enriched females also showed higher activation in the frontal cortex without differences in male groups. Moreover, the insular cortex was less activated in females than in males. Thus, our results indicate that environmental enrichment has different effects on neuroplasticity and social/agonistic behavior in FVB/N mice, suggesting the relevance of sexual dimorphism in response to environmental stimuli.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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