Factors Associated with Skin Cancers in People with Albinism in Togo.

Autor: Mouhari-Toure A; Service de Dermatolgie et IST, CHU Kara, Université de Kara, Kara, Togo., Akakpo SA; Service de Dermatolgie et IST, CHU Sylvanus Olympio, Université de Lomé, Lomé, Togo., Teclessou JN; Service de Dermatolgie et IST, CHU Campus Université de Lomé, Lomé, Togo., Gnossike P; Centre National de Dermatologie de Gbossimé, Lomé, Togo., Adam S; Service de Chirurgie Maxillo-faciale et Plastique, CHU Sylvanus Olympio, Université de Lomé, Lomé, Togo., Mahamadou G; Service de Dermatolgie et IST, CHU Sylvanus Olympio, Université de Lomé, Lomé, Togo., Kassang P; Service de Dermatolgie et IST, CHU Sylvanus Olympio, Université de Lomé, Lomé, Togo., Elegbede Y; Service de Dermatolgie et IST, Centre Hospitalier Régional de Tomdè, Kara, Togo., Darre T; Laboratoire D'anatomie et Cytotologie Pathologique, CHU Sylvanus Olympio, Université de Lomé, Lomé, Togo., Kombate K; Service de Dermatolgie et IST, CHU Campus Université de Lomé, Lomé, Togo., Pitché P; Service de Dermatolgie et IST, CHU Sylvanus Olympio, Université de Lomé, Lomé, Togo., Saka B; Service de Dermatolgie et IST, CHU Sylvanus Olympio, Université de Lomé, Lomé, Togo.
Jazyk: angličtina
Zdroj: Journal of skin cancer [J Skin Cancer] 2021 Dec 23; Vol. 2021, pp. 3433493. Date of Electronic Publication: 2021 Dec 23 (Print Publication: 2021).
DOI: 10.1155/2021/3433493
Abstrakt: Objective: The aim of this study was to identify the factors associated with skin cancers in people with albinism (PWA) in Togo.
Method: This is a retrospective analytical study of the records of PWA examined during five dermatological consultation campaigns from 2019 to 2021.
Results: During the study period, 517 PWA were seen. Sixty-four (12.3%) of these PWA had presented with 137 cases of skin cancer. The sex ratio (M/F) was 0.9. The average age of PWA with skin cancer was 39.69 ± 15.61 years and that of PWA without skin cancer was 19.17 ± 15.24 years ( p ≤ 0.001). The 137 cases of skin cancers were dominated by basal cell carcinomas (45.9%). These skin cancers were located preferentially in the cephalic region (77 cases; 56.2%), followed by the upper limbs (33 cases; 24.1%). In multivariate analysis, the risk factors for skin cancers in PWA were age over 39 years ( p ≤ 0.001) and the presence of actinic keratoses ( p ≤ 0.001). In contrast, the presence of ephelides ( p =0.018) was a protective factor.
Conclusion: This study confirms that advanced age and actinic keratoses are risk factors for skin cancer in PWA, in connection with the cumulative role of solar radiation. Its originality lies in the identification of ephelides as a protective factor. The knowledge and consideration of these risk factors will make it possible to optimise strategies for the prevention of skin cancers in PWA.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2021 Abas Mouhari-Toure et al.)
Databáze: MEDLINE
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