Layer-specific activation in human primary somatosensory cortex during tactile temporal prediction error processing.

Autor: Yu Y; Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 3-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan; Section on Functional Imaging Methods, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA. Electronic address: yinghua.yyh@gmail.com., Huber L; MR-Methods Group, MBIC, Cognitive Neuroscience Department, Faculty of Psychology and Neuroscience, University of Maastricht, Cognitive Neuroscience, Room 1.014, Oxfordlaan 55, 6229 EV Maastricht, The Netherlands., Yang J; Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 3-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan; Section on Functional Imaging Methods, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA., Fukunaga M; Division of Cerebral Research, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi, 444-8585 Japan., Chai Y; Section on Functional Imaging Methods, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA., Jangraw DC; Section on Functional Imaging Methods, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA., Chen G; Scientific and Statistical Computational Core, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA., Handwerker DA; Section on Functional Imaging Methods, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA., Molfese PJ; Section on Functional Imaging Methods, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA., Ejima Y; Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 3-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan., Sadato N; Division of Cerebral Research, National Institute for Physiological Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi, 444-8585 Japan., Wu J; Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, 3-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan; Beijing Institute of Technology, 5 South Zhongguancun Street, Hiadian District, Beijing 100081, China., Bandettini PA; Section on Functional Imaging Methods, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA; Functional MRI Core Facility, National Institute of Mental Health, Building 10, 10 Center Dr Bethesda, MD 20892, USA.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2022 Mar; Vol. 248, pp. 118867. Date of Electronic Publication: 2021 Dec 30.
DOI: 10.1016/j.neuroimage.2021.118867
Abstrakt: The human brain continuously generates predictions of incoming sensory input and calculates corresponding prediction errors from the perceived inputs to update internal predictions. In human primary somatosensory cortex (area 3b), different cortical layers are involved in receiving the sensory input and generation of error signals. It remains unknown, however, how the layers in the human area 3b contribute to the temporal prediction error processing. To investigate prediction error representation in the area 3b across layers, we acquired layer-specific functional magnetic resonance imaging (fMRI) data at 7T from human area 3b during a task of index finger poking with no-delay, short-delay and long-delay touching sequences. We demonstrate that all three tasks increased activity in both superficial and deep layers of area 3b compared to the random sensory input. The fMRI signal was differentially modulated solely in the deep layers rather than the superficial layers of area 3b by the delay time. Compared with the no-delay stimuli, activity was greater in the deep layers of area 3b during the short-delay stimuli but lower during the long-delay stimuli. This difference activity features in the superficial and deep layers suggest distinct functional contributions of area 3b layers to tactile temporal prediction error processing. The functional segregation in area 3b across layers may reflect that the excitatory and inhibitory interplay in the sensory cortex contributions to flexible communication between cortical layers or between cortical areas.
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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