Pediatric patch testing in a multi-ethnic Asian population: A retrospective review.

Autor: Lee EY; Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore, Singapore., Wee CLP; Department of Dermatology, National Skin Centre, Singapore, Singapore., Tan CH; Department of Dermatology, National Skin Centre, Singapore, Singapore., Wee LWY; Dermatology Service, KK Women's and Children's Hospital, Singapore, Singapore., Lim CE; Dermatology Service, KK Women's and Children's Hospital, Singapore, Singapore., Zhao X; Research Department, National Skin Centre, Singapore, Singapore., Koh MJA; Dermatology Service, KK Women's and Children's Hospital, Singapore, Singapore., Yew YW; Department of Dermatology, National Skin Centre, Singapore, Singapore.; Research Department, National Skin Centre, Singapore, Singapore., Goon ATJ; Department of Dermatology, National Skin Centre, Singapore, Singapore.
Jazyk: angličtina
Zdroj: Pediatric dermatology [Pediatr Dermatol] 2022 Jan; Vol. 39 (1), pp. 69-76. Date of Electronic Publication: 2021 Dec 31.
DOI: 10.1111/pde.14904
Abstrakt: Background: Pediatric allergic contact dermatitis (ACD) is increasingly prevalent. Patch testing is the gold-standard diagnostic investigation. The aims of our study were to describe the clinical profile of pediatric patients with ACD in a multi-ethnic Asian population and identify the common contact allergens.
Methods: This was a retrospective study involving children and adolescents aged 16 years or younger with clinically suspected ACD who underwent patch testing between January 2007 and March 2020 at two institutions in Singapore. Information pertaining to their demographics, atopy history, clinical presentation, and patch test results was analyzed.
Results: A total of 252 patients were included. The mean age was 10.9 years (1.0-16.7 years). The majority were Chinese (79.8%) and girls (57.5%). Many (66.3%) had atopic dermatitis (AD), which was mild. The most common presentation was an acral eczematous rash. The sensitization rate was 50.0%. The most frequent reactions were to nickel sulfate (49.2%) and fragrance mix (19.1%). The overall rate of relevant positive patch tests was 72.5%. Patients with AD were less likely to have a reaction to fragrance mix (p = .019) and more likely to have a reaction to disperse blue (p = .041). Compared to younger children, adolescents were less likely to have a positive patch test (p = .008). Indians were also less likely to have a positive reaction (p = .004).
Conclusion: Metals and fragrances were the most common allergens causing childhood ACD in Singapore. Patients with AD were less likely to be sensitized to fragrances and more likely to be sensitized to disperse blue dye.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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