Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary.

Autor:	Bembea MM; Department of Anesthesiology and Critical Care Medicine., Agus M; Division of Medical Critical Care., Akcan-Arikan A; Sections of Critical Care and Nephrology., Alexander P; Department of Cardiology.; Department of Pediatrics, Boston Children's Hospital., Basu R; Division of Pediatric Critical Care, Children's Healthcare of Atlanta., Bennett TD; Sections of Informatics and Data Science and Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado., Bohn D; Department of Critical Care Medicine., Brandão LR; Division of Hematology-Oncology, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada., Brown AM; Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia., Carcillo JA; Division of Pediatric Critical Care Medicine, Department of Critical Care Medicine, University of Pittsburgh School of Medicine., Checchia P; Section of Critical Care Medicine, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas., Cholette J; Department of Pediatrics, University of Rochester Golisano Children's Hospital, Rochester, New York., Cheifetz IM; Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio., Cornell T; Division of Pediatric Critical Care Medicine, Department of Pediatrics, Stanford University School of Medicine, Lucile Packard Children's Hospital Stanford, Palo Alto, California., Doctor A; Center for Blood Oxygen Transport and Hemostasis, University of Maryland School of Medicine, Baltimore, Maryland., Eckerle M; Department of Pediatrics, University of Cincinnati College of Medicine.; Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Erickson S; Department of Paediatric Critical Care; Perth Children's Hospital and University of Western Australia, Perth, Western Australia, Australia., Farris RWD; Department of Pediatrics, Seattle Children's Hospital, University of Washington Seattle, Washington., Faustino EVS; Section of Pediatric Critical Care Medicine, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut., Fitzgerald JC; Department of Anesthesiology and Critical Care, The University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Fuhrman DY; Division of Pediatric Critical Care Medicine, Department of Critical Care Medicine, University of Pittsburgh School of Medicine., Giuliano JS; Section of Pediatric Critical Care Medicine, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut., Guilliams K; Division of Pediatric and Development Neurology, Department of Neurology, and Division of Pediatric Critical Care Medicine., Gaies M; Department of Pediatrics, University of Michigan, Ann Arbor, Michigan., Gorga SM; Department of Pediatrics, University of Michigan, Ann Arbor, Michigan., Hall M; Division of Critical Care Medicine, Department of Pediatrics, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio., Hanson SJ; Critical Care Section, Department of Pediatrics, Medical College of Wisconsin/Children's Wisconsin, Milwaukee, Wisconsin., Hartman M; Department of Anesthesiology and Critical Care Medicine., Hassinger AB; Division of Medical Critical Care., Irving SY; Sections of Critical Care and Nephrology., Jeffries H; Department of Pediatrics, Seattle Children's Hospital, University of Washington Seattle, Washington., Jouvet P; Department of Cardiology., Kannan S; Department of Anesthesiology and Critical Care Medicine., Karam O; Department of Pediatrics, Boston Children's Hospital., Khemani RG; Division of Pediatric Critical Care, Children's Healthcare of Atlanta., Kissoon N; Sections of Informatics and Data Science and Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado., Lacroix J; Department of Critical Care Medicine., Laussen P; Department of Cardiology.; Department of Pediatrics, Boston Children's Hospital.; Division of Hematology-Oncology, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada., Leclerc F; Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia., Lee JH; Division of Pediatric Critical Care Medicine, Department of Critical Care Medicine, University of Pittsburgh School of Medicine., Leteurtre S; Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia., Lobner K; Section of Critical Care Medicine, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas., McKiernan PJ; Department of Pediatrics, University of Rochester Golisano Children's Hospital, Rochester, New York., Menon K; Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio., Monagle P; Division of Pediatric Critical Care Medicine, Department of Pediatrics, Stanford University School of Medicine, Lucile Packard Children's Hospital Stanford, Palo Alto, California., Muszynski JA; Division of Critical Care Medicine, Department of Pediatrics, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio., Odetola F; Department of Pediatrics, University of Michigan, Ann Arbor, Michigan., Parker R; Center for Blood Oxygen Transport and Hemostasis, University of Maryland School of Medicine, Baltimore, Maryland., Pathan N; Department of Pediatrics, University of Cincinnati College of Medicine., Pierce RW; Section of Pediatric Critical Care Medicine, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut., Pineda J; Division of Pediatric Critical Care, Children's Healthcare of Atlanta., Prince JM; Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio., Robinson KA; Department of Paediatric Critical Care; Perth Children's Hospital and University of Western Australia, Perth, Western Australia, Australia., Rowan CM; Department of Pediatrics, Seattle Children's Hospital, University of Washington Seattle, Washington., Ryerson LM; Section of Pediatric Critical Care Medicine, Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut., Sanchez-Pinto LN; Department of Anesthesiology and Critical Care, The University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Schlapbach LJ; Division of Pediatric and Development Neurology, Department of Neurology, and Division of Pediatric Critical Care Medicine., Selewski DT; Department of Pediatrics, University of Michigan, Ann Arbor, Michigan., Shekerdemian LS; Section of Critical Care Medicine, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas., Simon D; Division of Pediatric Critical Care Medicine, Department of Critical Care Medicine, University of Pittsburgh School of Medicine., Smith LS; Department of Pediatrics, Seattle Children's Hospital, University of Washington Seattle, Washington., Squires JE; Department of Pediatrics, University of Rochester Golisano Children's Hospital, Rochester, New York., Squires RH; Department of Pediatrics, University of Rochester Golisano Children's Hospital, Rochester, New York., Sutherland SM; Division of Critical Care Medicine, Department of Pediatrics, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio., Ouellette Y; Critical Care Section, Department of Pediatrics, Medical College of Wisconsin/Children's Wisconsin, Milwaukee, Wisconsin., Spaeder MC; Department of Anesthesiology and Critical Care Medicine., Srinivasan V; Department of Anesthesiology and Critical Care, The University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Steiner ME; Division of Medical Critical Care., Tasker RC; Division of Hematology-Oncology, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada., Thiagarajan R; Department of Cardiology.; Department of Pediatrics, Boston Children's Hospital., Thomas N; Sections of Critical Care and Nephrology., Tissieres P; Department of Cardiology., Traube C; Department of Pediatrics, Boston Children's Hospital., Tucci M; Department of Critical Care Medicine., Typpo KV; Division of Pediatric Critical Care, Children's Healthcare of Atlanta., Wainwright MS; Sections of Informatics and Data Science and Critical Care Medicine, Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado., Ward SL; Department of Critical Care Medicine., Watson RS; Department of Pediatrics, Seattle Children's Hospital, University of Washington Seattle, Washington., Weiss S; Department of Anesthesiology and Critical Care, The University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Whitney J; Division of Medical Critical Care., Willson D; Department of Pediatrics, Boston Children's Hospital., Wynn JL; Division of Hematology-Oncology, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Ontario, Canada., Yehya N; Department of Anesthesiology and Critical Care, The University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Zimmerman JJ; Department of Pediatrics, Seattle Children's Hospital, University of Washington Seattle, Washington.
Jazyk:	angličtina
Zdroj:	Pediatrics [Pediatrics] 2022 Jan 01; Vol. 149 (1 Suppl 1), pp. S1-S12.
DOI:	10.1542/peds.2021-052888B
Abstrakt:	Prior criteria for organ dysfunction in critically ill children were based mainly on expert opinion. We convened the Pediatric Organ Dysfunction Information Update Mandate (PODIUM) expert panel to summarize data characterizing single and multiple organ dysfunction and to derive contemporary criteria for pediatric organ dysfunction. The panel was composed of 88 members representing 47 institutions and 7 countries. We conducted systematic reviews of the literature to derive evidence-based criteria for single organ dysfunction for neurologic, cardiovascular, respiratory, gastrointestinal, acute liver, renal, hematologic, coagulation, endocrine, endothelial, and immune system dysfunction. We searched PubMed and Embase from January 1992 to January 2020. Study identification was accomplished using a combination of medical subject headings terms and keywords related to concepts of pediatric organ dysfunction. Electronic searches were performed by medical librarians. Studies were eligible for inclusion if the authors reported original data collected in critically ill children; evaluated performance characteristics of scoring tools or clinical assessments for organ dysfunction; and assessed a patient-centered, clinically meaningful outcome. Data were abstracted from each included study into an electronic data extraction form. Risk of bias was assessed using the Quality in Prognosis Studies tool. Consensus was achieved for a final set of 43 criteria for pediatric organ dysfunction through iterative voting and discussion. Although the PODIUM criteria for organ dysfunction were limited by available evidence and will require validation, they provide a contemporary foundation for researchers to identify and study single and multiple organ dysfunction in critically ill children. Competing Interests: FINANCIAL DISCLOSURE: The authors have indicated they have no financial relationships relevant to this article to disclose. (Copyright © 2022 by the American Academy of Pediatrics.)
Databáze:	MEDLINE
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