A clinicopathologic analysis of 54 cases of cutaneous myxoma.

Autor: Sharma A; Department of Pathology, Cleveland Clinic, Cleveland, OH, 44195, United States. Electronic address: anurag.sharma.pathology@gmail.com., Khaitan N; Department of Pathology, Cleveland Clinic, Cleveland, OH, 44195, United States., Ko JS; Department of Pathology, Cleveland Clinic, Cleveland, OH, 44195, United States., Bergfeld WF; Department of Pathology, Cleveland Clinic, Cleveland, OH, 44195, United States; Department of Dermatology, Cleveland Clinic, Cleveland, OH, 44195, United States., Piliang M; Department of Pathology, Cleveland Clinic, Cleveland, OH, 44195, United States; Department of Dermatology, Cleveland Clinic, Cleveland, OH, 44195, United States., Rubin BP; Department of Pathology, Cleveland Clinic, Cleveland, OH, 44195, United States., Goldblum JR; Department of Pathology, Cleveland Clinic, Cleveland, OH, 44195, United States., Billings SD; Department of Pathology, Cleveland Clinic, Cleveland, OH, 44195, United States.
Jazyk: angličtina
Zdroj: Human pathology [Hum Pathol] 2022 Feb; Vol. 120, pp. 71-76. Date of Electronic Publication: 2021 Dec 27.
DOI: 10.1016/j.humpath.2021.12.003
Abstrakt: Cutaneous myxoma (CM) is an uncommon benign neoplasm of skin, which may be sporadic or arise in association with syndromes such as Carney complex. There has been only one large case series describing CM. We report 54 additional cases of CM; patients had a mean age of 55 years (range = 7-91), with a female-to-male ratio of 1.3. Most occurred on the trunk (n = 19), with the back being the most common site. The remainder presented on the lower extremity (n = 18), head and neck (n = 10), and arm (n = 7). Histopathologically, they were relatively circumscribed, nodular, and centered in the dermis. All had abundant myxoid stroma, a thin, arborizing vascular network, and spindled to stellate cells with no to mild atypia without mitotic activity. Follicular induction, stromal neutrophils, and intranuclear inclusions were present in 35%, 25%, and 61% of cases, respectively. Collagen trapping, splitting of collagen fibers, and encircling of hair follicles or eccrine glands were encountered in a subset. Thirty-nine cases were treated with shave excision, whereas 12 cases underwent wide local excision. Follow-up data were available for 28 of 54 cases (mean = 50 months). Only one case recurred at 36 months. This study suggests CM has a lower risk of local recurrence than previously reported.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: