The molecular ontogeny of follicular lymphoma: gene mutations succeeding the BCL2 translocation define common precursor cells.

Autor: Haebe S; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany.; Department of Medicine III, Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany., Keay W; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany.; Department of Medicine III, Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany., Alig S; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany.; Department of Medicine III, Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany., Mohr AW; Helmholtz Center Munich, German Research Center for Environmental Health, Research Unit Gene Vectors, Munich, Germany., Martin LK; Helmholtz Center Munich, German Research Center for Environmental Health, Research Unit Gene Vectors, Munich, Germany., Heide M; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany.; Department of Medicine III, Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany., Secci R; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), Munich, Germany., Krebs S; Laboratory for Functional Genome Analysis, Gene Center, Ludwig-Maximilians-University (LMU) of Munich, Munich, Germany., Blum H; Laboratory for Functional Genome Analysis, Gene Center, Ludwig-Maximilians-University (LMU) of Munich, Munich, Germany., Moosmann A; Department of Medicine III, Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany.; DZIF Research Group Host Control of Viral Latency and Reactivation, DZIF - German Center for Infection Research, Munich, Germany., Louissaint A Jr; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Weinstock DM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Thoene S; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), Munich, Germany.; German Cancer Consortium (DKTK), Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., von Bergwelt-Baildon M; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany.; Department of Medicine III, Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany.; German Cancer Consortium (DKTK), Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Ruland J; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, Munich, Germany.; Center for Translational Cancer Research (TranslaTUM), Munich, Germany.; German Cancer Consortium (DKTK), Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Bararia D; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany.; Department of Medicine III, Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany.; German Cancer Consortium (DKTK), Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Weigert O; Laboratory for Experimental Leukemia and Lymphoma Research (ELLF), Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany.; Department of Medicine III, Hospital of the Ludwig-Maximilians-University (LMU), Munich, Germany.; German Cancer Consortium (DKTK), Munich, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jazyk: angličtina
Zdroj: British journal of haematology [Br J Haematol] 2022 Mar; Vol. 196 (6), pp. 1381-1387. Date of Electronic Publication: 2021 Dec 29.
DOI: 10.1111/bjh.17990
Abstrakt: Relapsed follicular lymphoma (FL) can arise from common progenitor cells (CPCs). Conceptually, CPC-defining mutations are somatic alterations shared by the initial and relapsed tumours, mostly B-cell leukaemia/lymphoma 2 (BCL2)/immunoglobulin heavy locus (IGH) translocations and other recurrent gene mutations. Through complementary approaches for highly sensitive mutation detection, we do not find CPC-defining mutations in highly purified BCL2/IGH-negative haematopoietic progenitor cells in clinical remission samples from three patients with relapsed FL. Instead, we find cells harbouring the same BCL2/IGH translocation but lacking CREB binding protein (CREBBP), lysine methyltransferase 2D (KMT2D) and other recurrent gene mutations. Thus, (i) the BCL2/IGH translocation can precede CPC-defining mutations in human FL, and (ii) BCL2/IGH-translocated cells can persist in clinical remission.
(© 2021 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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